3-{5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-3,4-dihydro-2H-quinolin-1-yl}-1,1,1-trifluoro-propan-2-ol

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Chemical Name:3-{5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-3,4-dihydro-2H-quinolin-1-yl}-1,1,1-trifluoro-propan-2-ol
CAS No.:957212-53-2
Molecular Formula:C₂₀H₁₇BrF₇NO₂
Molecular Weight:516.253
Hs Code.:

Synonyms:3-{5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-3,4-dihydro-2H-quinolin-1-yl}-1,1,1-trifluoro-propan-2-ol

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Chemical Property of 3-{5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-3,4-dihydro-2H-quinolin-1-yl}-1,1,1-trifluoro-propan-2-ol

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Technology Process of 3-{5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-3,4-dihydro-2H-quinolin-1-yl}-1,1,1-trifluoro-propan-2-ol

There total 2 articles about 3-{5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-3,4-dihydro-2H-quinolin-1-yl}-1,1,1-trifluoro-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 359-41-1
1,1,1-trifluoro-2,3-epoxypropane

: C₂₃H₁₇BrF₄N₂O₅S

: 957212-53-2
3-{5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-3,4-dihydro-2H-quinolin-1-yl}-1,1,1-trifluoro-propan-2-ol

Guidance literature:: C₂₃H₁₇BrF₄N₂O₅S; With mercaptoacetic acid; lithium hydroxide; In N,N-dimethyl-formamide;

1,1,1-trifluoro-2,3-epoxypropane; With ytterbium(III) triflate; In 1,2-dichloro-ethane; at 50 ℃;
DOI:10.1016/j.bmcl.2009.03.051

Reference yield:

: 957212-53-2
3-{5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-3,4-dihydro-2H-quinolin-1-yl}-1,1,1-trifluoro-propan-2-ol

Guidance literature:

Reference yield: 45.0%

: 957212-53-2
3-{5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-3,4-dihydro-2H-quinolin-1-yl}-1,1,1-trifluoro-propan-2-ol

: 14143-32-9
4-chloro-3-ethylphenol

: 957212-74-7
5-(4-chloro-3-ethyl-phenoxy)-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-quinoline

Guidance literature:: With 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(l) chloride; In 1-methyl-pyrrolidin-2-one; at 120 ℃;
DOI:10.1016/j.bmcl.2009.03.051