Diisopropyl-phosphoramidous acid 2-cyano-ethyl ester (1S,2S,5S)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-cyclohexyl ester

Base Information

Chemical Name:Diisopropyl-phosphoramidous acid 2-cyano-ethyl ester (1S,2S,5S)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-cyclohexyl ester
CAS No.:878550-10-8
Molecular Formula:C₃₉H₄₇N₄O₆P
Molecular Weight:698.799
Hs Code.:

Diisopropyl-phosphoramidous acid 2-cyano-ethyl ester (1S,2S,5S)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-cyclohexyl ester

Synonyms:Diisopropyl-phosphoramidous acid 2-cyano-ethyl ester (1S,2S,5S)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-cyclohexyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid 2-cyano-ethyl ester (1S,2S,5S)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-cyclohexyl ester

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Technology Process of Diisopropyl-phosphoramidous acid 2-cyano-ethyl ester (1S,2S,5S)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-cyclohexyl ester

There total 11 articles about Diisopropyl-phosphoramidous acid 2-cyano-ethyl ester (1S,2S,5S)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 878550-08-4
1-{2'-hydroxy-4'-[(4-methoxyphenyl)diphenylmethoxy]cyclohexyl}uracil

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 878550-10-8
Diisopropyl-phosphoramidous acid 2-cyano-ethyl ester (1S,2S,5S)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-cyclohexyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.75h;
DOI:10.1002/hlca.200590258

Reference yield:

: (+/-)-1-[(1'RS,2'RS,4'RS)-4'-(benzyloxy)-2'-hydroxycyclohexyl]uracil

: 878550-10-8
Diisopropyl-phosphoramidous acid 2-cyano-ethyl ester (1S,2S,5S)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-cyclohexyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / 1H-imidazole / dimethylformamide / 4 h / 20 °C

2: 95 percent / BCl₃ / CH₂Cl₂ / 4 h / -78 °C

3: 39 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 20 °C

4: 91 percent / NaOH / methanol; dioxane

5: 100 percent / pyridine

6: 70 percent / Bu₄NF / tetrahydrofuran

7: 78 percent / EtN(i-Pr)2 / CH₂Cl₂ / 0.75 h / 20 °C

With pyridine; 1H-imidazole; dmap; sodium hydroxide; tetrabutyl ammonium fluoride; boron trichloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200590258

Reference yield:

: (+/-)-N-({[(1'RS,2'RS,4'RS)-4'-(benzyloxy)-2'-hydroxycyclohexyl]amino}carbonyl)adenine

: 878550-10-8
Diisopropyl-phosphoramidous acid 2-cyano-ethyl ester (1S,2S,5S)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxy]-cyclohexyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 73 percent / H₂SO₄ / H₂O / 2 h / Heating

2: 95 percent / 1H-imidazole / dimethylformamide / 4 h / 20 °C

3: 95 percent / BCl₃ / CH₂Cl₂ / 4 h / -78 °C

4: 39 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 20 °C

5: 91 percent / NaOH / methanol; dioxane

6: 100 percent / pyridine

7: 70 percent / Bu₄NF / tetrahydrofuran

8: 78 percent / EtN(i-Pr)2 / CH₂Cl₂ / 0.75 h / 20 °C

With pyridine; 1H-imidazole; dmap; sodium hydroxide; sulfuric acid; tetrabutyl ammonium fluoride; boron trichloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200590258