(2S,3S,1'S)-3-(tert-butyl-dimethyl-silanyloxy)-2-(1-phenyl-ethyl)-octanoic acid methyl ester

Base Information

Chemical Name:(2S,3S,1'S)-3-(tert-butyl-dimethyl-silanyloxy)-2-(1-phenyl-ethyl)-octanoic acid methyl ester
CAS No.:917590-88-6
Molecular Formula:C₂₃H₄₀O₃Si
Molecular Weight:392.654
Hs Code.:

Synonyms:(2S,3S,1'S)-3-(tert-butyl-dimethyl-silanyloxy)-2-(1-phenyl-ethyl)-octanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,1'S)-3-(tert-butyl-dimethyl-silanyloxy)-2-(1-phenyl-ethyl)-octanoic acid methyl ester

Chemical Property:

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Technology Process of (2S,3S,1'S)-3-(tert-butyl-dimethyl-silanyloxy)-2-(1-phenyl-ethyl)-octanoic acid methyl ester

There total 1 articles about (2S,3S,1'S)-3-(tert-butyl-dimethyl-silanyloxy)-2-(1-phenyl-ethyl)-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 917590-80-8
(2S,3S,1'S)-3-hydroxy-2-(1-phenyl-ethyl)-octanoic acid methyl ester

: 69739-34-0
t-butyldimethylsiyl triflate

: 917590-88-6
(2S,3S,1'S)-3-(tert-butyl-dimethyl-silanyloxy)-2-(1-phenyl-ethyl)-octanoic acid methyl ester

Guidance literature:: With 2,6-dimethylpyridine; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/ja0651862

Reference yield:

: 917590-88-6
(2S,3S,1'S)-3-(tert-butyl-dimethyl-silanyloxy)-2-(1-phenyl-ethyl)-octanoic acid methyl ester

: 109667-12-1
(2S,3S,4S)-4-methyl-5-oxo-2-pentyltetrahydrofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / NaIO₄ / RuCl₃*xH₂O / acetonitrile; ethyl acetate; H₂O / 16 h / 20 °C

2: 91 percent / aq. HBr / 3 h / Heating

With sodium periodate; hydrogen bromide; ruthenium trichloride; In water; ethyl acetate; acetonitrile;
DOI:10.1021/ja0651862