1-[7-((Methanesulfonyl)oxy)naphthyl]-4-[2-(1-triphenylmethyl-4-imidazolyl)-ethyl]-2-piperazinone

Base Information

Chemical Name:1-[7-((Methanesulfonyl)oxy)naphthyl]-4-[2-(1-triphenylmethyl-4-imidazolyl)-ethyl]-2-piperazinone
CAS No.:476494-04-9
Molecular Formula:C₃₉H₃₆N₄O₄S
Molecular Weight:656.805
Hs Code.:

Synonyms:1-[7-((Methanesulfonyl)oxy)naphthyl]-4-[2-(1-triphenylmethyl-4-imidazolyl)-ethyl]-2-piperazinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[7-((Methanesulfonyl)oxy)naphthyl]-4-[2-(1-triphenylmethyl-4-imidazolyl)-ethyl]-2-piperazinone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[7-((Methanesulfonyl)oxy)naphthyl]-4-[2-(1-triphenylmethyl-4-imidazolyl)-ethyl]-2-piperazinone

There total 7 articles about 1-[7-((Methanesulfonyl)oxy)naphthyl]-4-[2-(1-triphenylmethyl-4-imidazolyl)-ethyl]-2-piperazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23147-58-2,110822-84-9,110822-85-0,77431-49-3
glycolaldehyde dimer

: 476494-03-8
methanesulfonic acid 8-{2-[2-(1-trityl-1H-imidazol-4-yl)-ethylamino]-acetylamino}-naphthalen-2-yl ester

: 476494-04-9
1-[7-((Methanesulfonyl)oxy)naphthyl]-4-[2-(1-triphenylmethyl-4-imidazolyl)-ethyl]-2-piperazinone

Guidance literature:: glycolaldehyde dimer; methanesulfonic acid 8-{2-[2-(1-trityl-1H-imidazol-4-yl)-ethylamino]-acetylamino}-naphthalen-2-yl ester; With sodium cyanoborohydride; In methanol; at 20 ℃;

With tributylphosphine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/S0960-894X(02)00154-3

Reference yield:

: 51-45-6
histamine

: 476494-04-9
1-[7-((Methanesulfonyl)oxy)naphthyl]-4-[2-(1-triphenylmethyl-4-imidazolyl)-ethyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2.1: 100 percent / Et₃N / dimethylformamide / 0 - 20 °C

3.1: 100 percent / aq. NaOH / methanol / 20 °C

4.1: DIEA / acetonitrile / 20 °C

5.1: NaBH₃CN / methanol / 20 °C

5.2: DTAD; n-Bu₃P / tetrahydrofuran / 0 - 20 °C

With sodium hydroxide; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 5.2: Mitsunobu reaction;
DOI:10.1016/S0960-894X(02)00154-3

Reference yield:

: 50580-77-3
2,2,2-trifluoro-N-[2-(1H-imidazol-4-yl)ethyl]acetamide

: 476494-04-9
1-[7-((Methanesulfonyl)oxy)naphthyl]-4-[2-(1-triphenylmethyl-4-imidazolyl)-ethyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / Et₃N / dimethylformamide / 0 - 20 °C

2.1: 100 percent / aq. NaOH / methanol / 20 °C

3.1: DIEA / acetonitrile / 20 °C

4.1: NaBH₃CN / methanol / 20 °C

4.2: DTAD; n-Bu₃P / tetrahydrofuran / 0 - 20 °C

With sodium hydroxide; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; acetonitrile; 4.2: Mitsunobu reaction;
DOI:10.1016/S0960-894X(02)00154-3