tert-butyl (S)-2-(5-(4-hydroxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (S)-2-(5-(4-hydroxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
• CAS No.: 1369392-15-3
• Molecular Formula: C₁₈H₂₃N₃O₃
• Molecular Weight: 329.399

Synonyms:tert-butyl (S)-2-(5-(4-hydroxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Chemical Property of tert-butyl (S)-2-(5-(4-hydroxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (S)-2-(5-(4-hydroxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

There total 9 articles about tert-butyl (S)-2-(5-(4-hydroxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-tert-butyl 2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (1007882-12-3) → tert-butyl (S)-2-(5-(4-hydroxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (1369392-15-3)

Guidance literature:

With water; dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; for 0.5h;

Reference yield: 47.0%

1-(tert-butyl) 2-(2-(4-hydroxyphenyl)-2-oxoethyl) (S)-pyrrolidine-1,2-dicarboxylate → tert-butyl (S)-2-(5-(4-hydroxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (1369392-15-3)

Guidance literature:

With ammonium acetate; In toluene; at 90 ℃; for 20h;

DOI:10.1016/j.ejmech.2016.09.031

Reference yield:

tert-butyl (S)-2-(5-(4-(benzyloxy)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (1616705-80-6) → tert-butyl (S)-2-(5-(4-hydroxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (1369392-15-3)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In methanol; ethyl acetate; at 20 ℃; Inert atmosphere;

upstream raw materials:

(S)-tert-butyl 2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

2-(2-(4-(benzyloxy)phenyl)-2-oxoethyl) 1-(tert-butyl) (S)-pyrrolidine-1,2-dicarboxylate

tert-butyl (S)-2-(5-(4-(benzyloxy)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

L-proline

Downstream raw materials:

C₄₁H₅₈N₆O₆Si

(S)-4-(2-(pyrrolidin-2-yl)-1H-imidazol-5-yl)phenol

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