1-[2-methyl-7-(2-pyrrolidin-1-yl-ethoxy)-1,2,3,4-tetrahydro-isoquinolin-4-yl]-cyclohexanol

Base Information

Chemical Name:1-[2-methyl-7-(2-pyrrolidin-1-yl-ethoxy)-1,2,3,4-tetrahydro-isoquinolin-4-yl]-cyclohexanol
CAS No.:1187948-12-4
Molecular Formula:C₂₂H₃₄N₂O₂
Molecular Weight:358.524
Hs Code.:

Synonyms:1-[2-methyl-7-(2-pyrrolidin-1-yl-ethoxy)-1,2,3,4-tetrahydro-isoquinolin-4-yl]-cyclohexanol

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Chemical Property of 1-[2-methyl-7-(2-pyrrolidin-1-yl-ethoxy)-1,2,3,4-tetrahydro-isoquinolin-4-yl]-cyclohexanol

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Technology Process of 1-[2-methyl-7-(2-pyrrolidin-1-yl-ethoxy)-1,2,3,4-tetrahydro-isoquinolin-4-yl]-cyclohexanol

There total 7 articles about 1-[2-methyl-7-(2-pyrrolidin-1-yl-ethoxy)-1,2,3,4-tetrahydro-isoquinolin-4-yl]-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1187948-21-5
2-methyl-7-(2-pyrrolidin-1-yl-ethoxy)-1,2,3,4-tetrahydro-isoquinoline

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1187948-12-4
1-[2-methyl-7-(2-pyrrolidin-1-yl-ethoxy)-1,2,3,4-tetrahydro-isoquinolin-4-yl]-cyclohexanol

Guidance literature:: 2-methyl-7-(2-pyrrolidin-1-yl-ethoxy)-1,2,3,4-tetrahydro-isoquinoline; With sec.-butyllithium; In toluene; at -78 ℃; for 2h;

cyclohexanone; In toluene; at -78 - 20 ℃; for 19h;

With hydrogenchloride; water; In toluene;

Reference yield:

: 109175-24-8
7-methoxy-2-methyl-3,4-dihydroisoquinolin-1(2H)-one

: 1187948-12-4
1-[2-methyl-7-(2-pyrrolidin-1-yl-ethoxy)-1,2,3,4-tetrahydro-isoquinolin-4-yl]-cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; hydrogen bromide / 100 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

5.1: sec.-butyllithium / toluene / 2 h / -78 °C

5.2: 19 h / -78 - 20 °C

With lithium aluminium tetrahydride; water; hydrogen bromide; sec.-butyllithium; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1187948-18-0
2-methyl-7-(2-pyrrolidin-1-yl-ethoxy)-3,4-dihydro-2H-isoquinolin-1-one

: 1187948-12-4
1-[2-methyl-7-(2-pyrrolidin-1-yl-ethoxy)-1,2,3,4-tetrahydro-isoquinolin-4-yl]-cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

2.1: sec.-butyllithium / toluene / 2 h / -78 °C

2.2: 19 h / -78 - 20 °C

With lithium aluminium tetrahydride; sec.-butyllithium; In tetrahydrofuran; toluene;