Technology Process of 3-Guanylic acid, 5-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(4-chlorophenyl)-2-deoxy-N-(2-methyl-1-oxopropyl)guanylyl-(3.5)-2-deoxy-N-(2-methyl-1-oxopropyl)-, 4-chlorophenyl 2-cyanoethyl ester
There total 8 articles about 3-Guanylic acid, 5-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(4-chlorophenyl)-2-deoxy-N-(2-methyl-1-oxopropyl)guanylyl-(3.5)-2-deoxy-N-(2-methyl-1-oxopropyl)-, 4-chlorophenyl 2-cyanoethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1-methylimidazole / acetonitrile / 2 h / 20 °C
2: 2percent benzenesulfonic acid / CHCl3; methanol
3: 1-(mesitylsulfonyl)tetrazole / pyridine / 0.75 h / Ambient temperature
With
1-methyl-1H-imidazole; 1-mesitylsulfonyl-1H-tetrazole; benzenesulfonic acid;
In
pyridine; methanol; chloroform; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) pyridine, 2.) 5percent aq. NH4HCO3 / 1.) dioxane, 30 min at room temp.; 2.) dioxane, cooling
2: 1-(mesitylsulfonyl)tetrazole / pyridine / 1 h / Ambient temperature
3: 1-methylimidazole / pyridine; acetonitrile / 1 h / Ambient temperature
With
pyridine; 1-methyl-1H-imidazole; 1-mesitylsulfonyl-1H-tetrazole; ammonium bicarbonate;
In
pyridine; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1-(mesitylsulfonyl)tetrazole / pyridine / 1 h / Ambient temperature
2: 1-methylimidazole / pyridine; acetonitrile / 1 h / Ambient temperature
With
1-methyl-1H-imidazole; 1-mesitylsulfonyl-1H-tetrazole;
In
pyridine; acetonitrile;