Technology Process of 4-fluoro-6-(4-isopropoxyphenyl)-2,2'-bipyridine
There total 3 articles about 4-fluoro-6-(4-isopropoxyphenyl)-2,2'-bipyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
cesium fluoride;
In
dimethyl sulfoxide;
at 140 ℃;
for 18h;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / tetrahydrofuran / 60 h / 60 °C / Sealed tube; Inert atmosphere
2: copper(l) iodide; cesium fluoride; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 2 h / 80 °C / Sealed tube; Inert atmosphere
3: cesium fluoride / dimethyl sulfoxide / 18 h / 140 °C / Sealed tube
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); cesium fluoride;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper(l) iodide; cesium fluoride; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 2 h / 80 °C / Sealed tube; Inert atmosphere
2: cesium fluoride / dimethyl sulfoxide / 18 h / 140 °C / Sealed tube
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); cesium fluoride;
In
dimethyl sulfoxide; N,N-dimethyl-formamide;
