Bromo-acetic acid (3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,5-dioxo-pyrrolidin-3-yl ester

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Chemical Name:Bromo-acetic acid (3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,5-dioxo-pyrrolidin-3-yl ester
CAS No.:187393-47-1
Molecular Formula:C₂₂H₃₂BrNO₇Si
Molecular Weight:530.488
Hs Code.:

Synonyms:Bromo-acetic acid (3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,5-dioxo-pyrrolidin-3-yl ester

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Chemical Property of Bromo-acetic acid (3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,5-dioxo-pyrrolidin-3-yl ester

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Technology Process of Bromo-acetic acid (3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,5-dioxo-pyrrolidin-3-yl ester

There total 2 articles about Bromo-acetic acid (3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,5-dioxo-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 598-21-0
2-Bromoacetyl bromide

: 187393-44-8
(2R,3R)-3,4-dihydroxy-1-[2-(3,4-dimethoxyphenyl)ethyl]pyrrolidine-2,5-dione

: 187393-47-1
Bromo-acetic acid (3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,5-dioxo-pyrrolidin-3-yl ester

Guidance literature:: With pyridine; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1016/S0040-4020(96)01179-9

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 187393-47-1
Bromo-acetic acid (3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,5-dioxo-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / xylene / 4 h / Heating

2: 98 percent / pyridine / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; In dichloromethane; xylene;
DOI:10.1016/S0040-4020(96)01179-9

Reference yield:

: 187393-47-1
Bromo-acetic acid (3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-2,5-dioxo-pyrrolidin-3-yl ester

: 187393-48-2
(6R,6aS)-6-(tert-Butyl-dimethyl-silanyloxy)-4-[2-(3,4-dimethoxy-phenyl)-ethyl]-6,6a-dihydro-4H-furo[3,2-b]pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 2 h / 50 °C

2: Et₃N / acetonitrile / 16 h / 50 °C

With triethylamine; In acetonitrile;
DOI:10.1016/S0040-4020(96)01179-9