(1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-(methyl-thiomethyl)cyclohexanol

Base Information

Chemical Name:(1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-(methyl-thiomethyl)cyclohexanol
CAS No.:1259279-85-0
Molecular Formula:C₁₂H₁₇ClFN₃OS
Molecular Weight:305.804
Hs Code.:

Synonyms:(1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-(methyl-thiomethyl)cyclohexanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-(methyl-thiomethyl)cyclohexanol

Chemical Property:

Purity/Quality:

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Technology Process of (1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-(methyl-thiomethyl)cyclohexanol

There total 3 articles about (1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-(methyl-thiomethyl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259279-73-6
2-chloro-5-fluoro-N-[(3S,5S)-1-oxaspiro[2.5]octan-5-yl]pyrimidin-4-amine

: 5188-07-8
sodium thiomethoxide

: 1259279-85-0
(1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-(methyl-thiomethyl)cyclohexanol

Guidance literature:: In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1259279-83-8
(S)-2-chloro-5-fluoro-N-(3-methylenecyclohexyl)pyrimidin-4-amine

: 1259279-85-0
(1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-(methyl-thiomethyl)cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: m-chloroperoxybenzoic acid / ethyl acetate; water; methanol

2: tetrahydrofuran

With m-chloroperoxybenzoic acid; In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

: (S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino) cyclohexanone

: 1259279-85-0
(1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-(methyl-thiomethyl)cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: ethyl acetate; lithium hexamethyldisilazane; tetrahydrofuran

2: m-chloroperoxybenzoic acid / ethyl acetate; water; methanol

3: tetrahydrofuran

With m-chloroperoxybenzoic acid; In tetrahydrofuran; methanol; water; ethyl acetate; lithium hexamethyldisilazane;