Technology Process of (2,6-Dimethyl-3,4-dioxo-cyclohexa-1,5-dienyl)-acetic acid (E)-2-(2,6-dimethyl-3,4-dioxo-cyclohexa-1,5-dienyl)-vinyl ester
There total 10 articles about (2,6-Dimethyl-3,4-dioxo-cyclohexa-1,5-dienyl)-acetic acid (E)-2-(2,6-dimethyl-3,4-dioxo-cyclohexa-1,5-dienyl)-vinyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 100 percent / KOH / ethanol / 12 h / Heating
2: HCl, H2 / 10percent Pd/C / ethanol / 8 h / 125 °C / 129287 Torr
3: H2SO4 / 6 h / Heating
4: 1.) K2CO3 / 1.) acetone, reflux, 30 min, 2.) reflux, 14 h
5: 98 percent / Diisobutylaluminum Hydride / diethyl ether; hexane / 0.5 h / -78 °C
6: 1.) lithium tetramethylpiperidide / 1.) THF, room temperature, 45 min, 2.) reflux, 3 h
7: 1.) trimethylsilyl iodide, triethylamine, 2.) CH3OH / 1.) CH3CN, 35-40 deg C, 2 h, 2.) reflux
8: 100 percent Spectr. / AgO, HNO3 / tetrahydrofuran / 0.08 h / Ambient temperature
With
hydrogenchloride; methanol; silver(II) oxide; potassium hydroxide; trimethylsilyl iodide; sulfuric acid; 2,2,6,6-tetramethylpiperidinyl-lithium; hydrogen; nitric acid; diisobutylaluminium hydride; potassium carbonate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; hexane;
DOI:10.1021/jo00343a003
- Guidance literature:
-
Multi-step reaction with 7 steps
1: HCl, H2 / 10percent Pd/C / ethanol / 8 h / 125 °C / 129287 Torr
2: H2SO4 / 6 h / Heating
3: 1.) K2CO3 / 1.) acetone, reflux, 30 min, 2.) reflux, 14 h
4: 98 percent / Diisobutylaluminum Hydride / diethyl ether; hexane / 0.5 h / -78 °C
5: 1.) lithium tetramethylpiperidide / 1.) THF, room temperature, 45 min, 2.) reflux, 3 h
6: 1.) trimethylsilyl iodide, triethylamine, 2.) CH3OH / 1.) CH3CN, 35-40 deg C, 2 h, 2.) reflux
7: 100 percent Spectr. / AgO, HNO3 / tetrahydrofuran / 0.08 h / Ambient temperature
With
hydrogenchloride; methanol; silver(II) oxide; trimethylsilyl iodide; sulfuric acid; 2,2,6,6-tetramethylpiperidinyl-lithium; hydrogen; nitric acid; diisobutylaluminium hydride; potassium carbonate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; hexane;
DOI:10.1021/jo00343a003
- Guidance literature:
-
Multi-step reaction with 6 steps
1: H2SO4 / 6 h / Heating
2: 1.) K2CO3 / 1.) acetone, reflux, 30 min, 2.) reflux, 14 h
3: 98 percent / Diisobutylaluminum Hydride / diethyl ether; hexane / 0.5 h / -78 °C
4: 1.) lithium tetramethylpiperidide / 1.) THF, room temperature, 45 min, 2.) reflux, 3 h
5: 1.) trimethylsilyl iodide, triethylamine, 2.) CH3OH / 1.) CH3CN, 35-40 deg C, 2 h, 2.) reflux
6: 100 percent Spectr. / AgO, HNO3 / tetrahydrofuran / 0.08 h / Ambient temperature
With
methanol; silver(II) oxide; trimethylsilyl iodide; sulfuric acid; 2,2,6,6-tetramethylpiperidinyl-lithium; nitric acid; diisobutylaluminium hydride; potassium carbonate; triethylamine;
In
tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/jo00343a003
