C₁₄H₁₇FO₅

Base Information

• Chemical Name: C₁₄H₁₇FO₅
• CAS No.: 947169-69-9
• Molecular Formula: C₁₄H₁₇FO₅
• Molecular Weight: 284.284
• Mol file: 947169-69-9.mol

Synonyms:C₁₄H₁₇FO₅

Chemical Property of C₁₄H₁₇FO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₄H₁₇FO₅

There total 1 articles about C₁₄H₁₇FO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-[(R)-1-(4-Fluoro-phenyl)-allyl]-malonic acid dimethyl ester (947169-85-9) → C14H17FO5 (947169-69-9) + C14H17FO5

Guidance literature:

2-[(R)-1-(4-Fluoro-phenyl)-allyl]-malonic acid dimethyl ester; With 9-borabicyclo[3.3.1]nonane dimer; RhCl(PPh₃)3; In tetrahydrofuran; at 20 ℃; for 12h;

With methanol; dihydrogen peroxide; at 20 ℃; for 12h; pH=7.0; Further stages. Title compound not separated from byproducts.;

DOI:10.1016/j.tetlet.2007.05.120

Reference yield:

C14H17FO5 (947169-69-9) → C13H14FNO3 (947169-72-4)

Guidance literature:

Multi-step reaction with 3 steps

1: NEt₃ / CH₂Cl₂ / 10 h / -30 °C

2: 225.3 mg / sodium azide / dimethylformamide / 24 h / 20 °C

3: 93 percent / hydrogen / Pd/CaCO₃ / toluene; methanol / 12 h / 760.05 Torr

With sodium azide; hydrogen; triethylamine; Lindlar's catalyst; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.tetlet.2007.05.120

Reference yield:

C14H17FO5 (947169-69-9) → (3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine (125224-43-3,188869-26-3)

Guidance literature:

Multi-step reaction with 4 steps

1: NEt₃ / CH₂Cl₂ / 10 h / -30 °C

2: 225.3 mg / sodium azide / dimethylformamide / 24 h / 20 °C

3: 93 percent / hydrogen / Pd/CaCO₃ / toluene; methanol / 12 h / 760.05 Torr

4: 99 percent / BH₃*THF / tetrahydrofuran / 18 h / Heating

With sodium azide; borane-THF; hydrogen; triethylamine; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.tetlet.2007.05.120

upstream raw materials:

2-[(R)-1-(4-Fluoro-phenyl)-allyl]-malonic acid dimethyl ester

Downstream raw materials:

C₁₄H₁₆FN₃O₄

C₁₃H₁₄FNO₃

(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine

Refernces