2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-yn-3-ol

Base Information

Chemical Name:2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-yn-3-ol
CAS No.:1398247-93-2
Molecular Formula:C₂₀H₃₂O₄Si
Molecular Weight:364.557
Hs Code.:

Synonyms:2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-yn-3-ol

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Chemical Property of 2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-yn-3-ol

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Technology Process of 2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-yn-3-ol

There total 5 articles about 2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-yn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 13361-64-3
trimethyl(propargyl)silane

: 1398247-66-9
2-[2-(2,5-dimethoxy-4-methylphenoxy)propan-2-yl]-oxirane

: 1398247-93-2
2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-yn-3-ol

Guidance literature:: trimethyl(propargyl)silane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

With boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

2-[2-(2,5-dimethoxy-4-methylphenoxy)propan-2-yl]-oxirane; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo3016055

Reference yield:

: 1398243-17-8
3-(2,5-dimethoxy-4-methylphenoxy)-3-methylbutane-1,2-diol

: 1398247-93-2
2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-yn-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; dmap / dichloromethane / 4 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / methanol / 1 h / 20 °C / Inert atmosphere

3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 0.17 h / -78 °C / Inert atmosphere

3.3: 1 h / -78 °C / Inert atmosphere

With dmap; n-butyllithium; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jo3016055

Reference yield:

: 73120-41-9
2,5-dimethoxy-4-methylphenol

: 1398247-93-2
2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-yn-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

2.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetone / 3.5 h / 20 °C

3.1: triethylamine; dmap / dichloromethane / 4 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / methanol / 1 h / 20 °C / Inert atmosphere

5.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

5.2: 0.17 h / -78 °C / Inert atmosphere

5.3: 1 h / -78 °C / Inert atmosphere

With dmap; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetone;
DOI:10.1021/jo3016055