(1S,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide

Base Information

Chemical Name:(1S,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide
CAS No.:1365990-86-8
Molecular Formula:C₁₆H₁₀Cl₂FN₃OS
Molecular Weight:382.245
Hs Code.:

Synonyms:(1S,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide

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Chemical Property of (1S,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide

Chemical Property:

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Technology Process of (1S,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide

There total 12 articles about (1S,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 167073-07-6,167073-08-7
(1SR,2SR)-2-fluorocyclopropanecarboxylic acid

: 1365993-06-1
2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-amine

: 1365990-86-8
(1S,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide

: 1365990-87-9
(1R,2R)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 120 ℃; for 4h; Microwave irradiation;

Reference yield:

: 1365991-84-9
(E)-3-(2-(2,6-dichlorophenyl)thiazol-4-yl)acrylic acid

: 1365990-86-8
(1S,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide

: 1365990-87-9
(1R,2R)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: sodium azide / 1,4-dioxane; water; acetone / 0 °C

3: 1,4-dioxane; diphenyl ether-biphenyl eutectic / 1.25 h / 230 °C

4: phosphorus(V) oxybromide / acetonitrile / 2 h / 100 °C

5: sodium t-butanolate; Benzophenone imine / tris-(dibenzylideneacetone)dipalladium(0); racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl / toluene / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 120 °C / Microwave irradiation

With Benzophenone imine; sodium azide; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; HATU; sodium t-butanolate; phosphorus(V) oxybromide; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,4-dioxane; diphenyl ether-biphenyl eutectic; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;

Reference yield:

: 1365991-85-0
(E)-3-(2-(2,6-dichlorophenyl)thiazol-4-yl)acryloyl chloride

: 1365990-86-8
(1S,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide

: 1365990-87-9
(1R,2R)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide / 1,4-dioxane; water; acetone / 0 °C

2: 1,4-dioxane; diphenyl ether-biphenyl eutectic / 1.25 h / 230 °C

3: phosphorus(V) oxybromide / acetonitrile / 2 h / 100 °C

4: sodium t-butanolate; Benzophenone imine / tris-(dibenzylideneacetone)dipalladium(0); racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl / toluene / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 120 °C / Microwave irradiation

With Benzophenone imine; sodium azide; N-ethyl-N,N-diisopropylamine; HATU; sodium t-butanolate; phosphorus(V) oxybromide; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; diphenyl ether-biphenyl eutectic; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;