2-[[4-[[2-(Trifluoromethyl)-phenyl]sulfonyl]-3,4-dihydro-2H-[1,4]benzoxazin-3-yl]-methoxy]-acetic acid

Base Information

Chemical Name:2-[[4-[[2-(Trifluoromethyl)-phenyl]sulfonyl]-3,4-dihydro-2H-[1,4]benzoxazin-3-yl]-methoxy]-acetic acid
CAS No.:1187964-02-8
Molecular Formula:C₁₈H₁₆F₃NO₆S
Molecular Weight:431.389
Hs Code.:

Synonyms:2-[[4-[[2-(Trifluoromethyl)-phenyl]sulfonyl]-3,4-dihydro-2H-[1,4]benzoxazin-3-yl]-methoxy]-acetic acid

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Chemical Property of 2-[[4-[[2-(Trifluoromethyl)-phenyl]sulfonyl]-3,4-dihydro-2H-[1,4]benzoxazin-3-yl]-methoxy]-acetic acid

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Technology Process of 2-[[4-[[2-(Trifluoromethyl)-phenyl]sulfonyl]-3,4-dihydro-2H-[1,4]benzoxazin-3-yl]-methoxy]-acetic acid

There total 11 articles about 2-[[4-[[2-(Trifluoromethyl)-phenyl]sulfonyl]-3,4-dihydro-2H-[1,4]benzoxazin-3-yl]-methoxy]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1187964-01-7
C₂₂H₂₄F₃NO₆S

: 1187964-02-8
2-[[4-[[2-(Trifluoromethyl)-phenyl]sulfonyl]-3,4-dihydro-2H-[1,4]benzoxazin-3-yl]-methoxy]-acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 100.0%

: 1186241-03-1
C₂₄H₃₁NO₇S

: 1187964-02-8
2-[[4-[[2-(Trifluoromethyl)-phenyl]sulfonyl]-3,4-dihydro-2H-[1,4]benzoxazin-3-yl]-methoxy]-acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 61396-67-6
rac-3-(2-nitrophenoxy)-1,2-propanediol

: 1187964-02-8
2-[[4-[[2-(Trifluoromethyl)-phenyl]sulfonyl]-3,4-dihydro-2H-[1,4]benzoxazin-3-yl]-methoxy]-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / 20 °C / Cooling with ice

2: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -78 - 20 °C

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 144 h / 2250.23 - 3750.38 Torr

4: pyridine / 48 h / 20 °C

5: water / ethanol / Heating

6: tetrabutyl-ammonium chloride; sodium hydroxide / dichloromethane; water / 20 °C / Cooling with ice

7: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With pyridine; oxalyl dichloride; tetrabutyl-ammonium chloride; water; hydrogen; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;