2-Chloro-6-hydroxypurine

Base Information

• Chemical Name: 2-Chloro-6-hydroxypurine
• CAS No.: 13368-14-4
• Molecular Formula: C5H3ClN4O
• Molecular Weight: 170.558
• Hs Code.: 2933990090
• Mol file: 13368-14-4.mol

Synonyms:Hypoxanthine,2-chloro- (6CI,7CI,8CI);2-Chloro-6-hydroxypurine;2-Chlorohypoxanthine;NSC12159;

Chemical Property of 2-Chloro-6-hydroxypurine

Chemical Property:

• Vapor Pressure: 0.00356mmHg at 25°C
• Melting Point: >300 °C
• Refractive Index: 1.91
• Boiling Point: 525.2°Cat760mmHg
• PKA: 7.95±0.20(Predicted)
• Flash Point: 271.4°C
• PSA: 74.69000
• Density: 2.09g/cm³
• LogP: 0.71190
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-1H-purin-6(7H)-one ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-6-hydroxypurine

There total 6 articles about 2-Chloro-6-hydroxypurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2,6-dichloro-7H-purine (5451-40-1) → 2-chlorohypoxanthine (13368-14-4)

Guidance literature:

With water; sodium hydroxide; at 90 ℃; Inert atmosphere;

Reference yield: 53.0%

guanine powder → 2-chloro-6-hydroxypurine (13368-14-4)

Guidance literature:

guanine powder; With hydrogenchloride; copper(l) chloride; In water; at 20 ℃; for 0.5h;

With sodium nitrite; In water; at -5 ℃;

DOI:10.5012/jkcs.2010.54.4.429

Reference yield:

concentrated sodium hydroxide + 2-chlorohypoxanthine-hydrochloride monohydrate → 2-chloro-1,7-dihydro-purin-6-one (13368-14-4)

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol;

upstream raw materials:

2,6-dichloro-7H-purine

Downstream raw materials:

2-hydrazino-1,7-dihydro-purin-6-one

9-(2-amino-2-deoxy-β-D-ribofuranosyl)-2-chlorohypoxanthine

2'-amino-2'-deoxyguanosine

2-amino-9-(tri-O-acetyl-β-D-arabinofuranosyl)-1,9-dihydro-purine-6-thione