Technology Process of 5-benzyloxy-7,9-dimethoxy-1,3-dimethyl-1H-benzo[g]isochromene
There total 10 articles about 5-benzyloxy-7,9-dimethoxy-1,3-dimethyl-1H-benzo[g]isochromene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
oxygen; copper dichloride; palladium dichloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
DOI:10.1039/b407208a
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 95 percent / guanidine hydrochloride; t-BuOK / ethanol; CH2Cl2 / 1.5 h / 20 °C
2.1: 99 percent / K2CO3 / acetone / 16 h / Heating
3.1: 75 percent / dimethylformamide / 12 h / 170 °C
4.1: 100 percent / K2CO3; KI / acetone / 18 h / Heating
5.1: 95 percent / LiAlH4 / tetrahydrofuran / 18 h / 20 °C
6.1: 78 percent / pyridinium chlorochromate; alumina / acetonitrile; CH2Cl2 / 8 h / 20 °C
7.1: magnesium / diethyl ether
7.2: 95 percent / diethyl ether; tetrahydrofuran / 8 h / 0 - 20 °C
8.1: 92 percent / oxygen; aq. CuCl2; PdCl2 / dimethylformamide / 3 h / 20 °C
With
aluminum oxide; lithium aluminium tetrahydride; potassium tert-butylate; oxygen; guanidine hydrochloride; potassium carbonate; magnesium; pyridinium chlorochromate; potassium iodide; copper dichloride; palladium dichloride;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
3.1: Claisen rearrangement / 7.2: Grignard addition / 8.1: Wacker oxidation;
DOI:10.1039/b407208a
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: t-BuOK / 2-methyl-propan-2-ol / 2 h / Heating
2.1: 8.10 g / sodium acetate / 2 h / 140 °C
3.1: 95 percent / guanidine hydrochloride; t-BuOK / ethanol; CH2Cl2 / 1.5 h / 20 °C
4.1: 99 percent / K2CO3 / acetone / 16 h / Heating
5.1: 75 percent / dimethylformamide / 12 h / 170 °C
6.1: 100 percent / K2CO3; KI / acetone / 18 h / Heating
7.1: 95 percent / LiAlH4 / tetrahydrofuran / 18 h / 20 °C
8.1: 78 percent / pyridinium chlorochromate; alumina / acetonitrile; CH2Cl2 / 8 h / 20 °C
9.1: magnesium / diethyl ether
9.2: 95 percent / diethyl ether; tetrahydrofuran / 8 h / 0 - 20 °C
10.1: 92 percent / oxygen; aq. CuCl2; PdCl2 / dimethylformamide / 3 h / 20 °C
With
aluminum oxide; lithium aluminium tetrahydride; potassium tert-butylate; oxygen; guanidine hydrochloride; sodium acetate; potassium carbonate; magnesium; pyridinium chlorochromate; potassium iodide; copper dichloride; palladium dichloride;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol;
1.1: Stobbe condensation / 5.1: Claisen rearrangement / 9.2: Grignard addition / 10.1: Wacker oxidation;
DOI:10.1039/b407208a
