3'-Tosyl-5'-O-trityl thymidine

Base Information

• Chemical Name: 3'-Tosyl-5'-O-trityl thymidine
• CAS No.: 141690-73-5
• Molecular Formula: C₃₆H₃₄N₂O₇S
• Molecular Weight: 638.741
• Mol file: 141690-73-5.mol

Synonyms:3'-Tosyl-5'-O-trityl thymidine

Chemical Property of 3'-Tosyl-5'-O-trityl thymidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-Tosyl-5'-O-trityl thymidine

There total 4 articles about 3'-Tosyl-5'-O-trityl thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

p-toluenesulfonyl chloride (98-59-9) + 5'-O-tritylthymidine (7791-71-1) → 3'-Tosyl-5'-O-trityl thymidine (141690-73-5)

Guidance literature:

With pyridine; for 32h; Ambient temperature;

DOI:10.1016/S0022-1139(00)82356-8

Reference yield:

trityl chloride (76-83-5) → 3'-Tosyl-5'-O-trityl thymidine (141690-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: pyridine

With pyridine;

Reference yield:

trityl chloride (76-83-5) → 3'-Tosyl-5'-O-trityl thymidine (141690-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0.5 h / steam bath

2: 85 percent / pyridine / 32 h / Ambient temperature

With pyridine;

DOI:10.1016/S0022-1139(00)82356-8

upstream raw materials:

p-toluenesulfonyl chloride

5'-O-tritylthymidine

trityl chloride

thymidine

Downstream raw materials:

3'-Fluoro-5'-O-trityl-deoxythymidine

1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-threo-pentofuranosyl)thymine

alovudine

5'-O-trityldeoxyxylothymidine