(2S,5S)-5-[4-Acetoxy-5-(diethoxy-phosphorylmethyl)-4'-methyl-biphenyl-3-ylmethyl]-2-tert-butyl-3-methyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:(2S,5S)-5-[4-Acetoxy-5-(diethoxy-phosphorylmethyl)-4'-methyl-biphenyl-3-ylmethyl]-2-tert-butyl-3-methyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester
CAS No.:174575-30-5
Molecular Formula:C₃₄H₄₉N₂O₈P
Molecular Weight:644.745
Hs Code.:

(2S,5S)-5-[4-Acetoxy-5-(diethoxy-phosphorylmethyl)-4'-methyl-biphenyl-3-ylmethyl]-2-tert-butyl-3-methyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester

Synonyms:(2S,5S)-5-[4-Acetoxy-5-(diethoxy-phosphorylmethyl)-4'-methyl-biphenyl-3-ylmethyl]-2-tert-butyl-3-methyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (2S,5S)-5-[4-Acetoxy-5-(diethoxy-phosphorylmethyl)-4'-methyl-biphenyl-3-ylmethyl]-2-tert-butyl-3-methyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (2S,5S)-5-[4-Acetoxy-5-(diethoxy-phosphorylmethyl)-4'-methyl-biphenyl-3-ylmethyl]-2-tert-butyl-3-methyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester

There total 6 articles about (2S,5S)-5-[4-Acetoxy-5-(diethoxy-phosphorylmethyl)-4'-methyl-biphenyl-3-ylmethyl]-2-tert-butyl-3-methyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 5720-05-8
4-methylphenylboronic acid

: 174575-07-6
1,1-dimethylethyl (2S,5S)-5-<<2-(acetyloxy)-5-bromo-3-<(diethoxyphosphoryl)methyl>phenyl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

: 174575-30-5
(2S,5S)-5-[4-Acetoxy-5-(diethoxy-phosphorylmethyl)-4'-methyl-biphenyl-3-ylmethyl]-2-tert-butyl-3-methyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With palladium diacetate; sodium carbonate; triphenylphosphine; In ethanol; toluene; at 100 ℃; ultrasonic bath;
DOI:10.1002/hlca.19950780810

Reference yield:

: 106-41-2
4-bromo-phenol

: 174575-30-5
(2S,5S)-5-[4-Acetoxy-5-(diethoxy-phosphorylmethyl)-4'-methyl-biphenyl-3-ylmethyl]-2-tert-butyl-3-methyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 48 percent / 1.) KOH / H₂O / 1.) 50 deg C, 40 min; 2.) 50 deg C, 36 h

2: 48percent aq. HBr / acetic acid / 1 h / 80 °C

3: 85 percent / conc. H₂SO₄ / acetic acid / 3 h / 60 °C

4: 42 percent / xylene / 2 h / Heating

5: 75 percent / (i-Pr)2NH, 1.6M BuLi / tetrahydrofuran; hexane / -70 °C

6: 85 percent / 2M aq. Na₂CO₃, PPh₃, Pd(OAc)2 / ethanol; toluene / 100 °C / ultrasonic bath

With palladium diacetate; potassium hydroxide; n-butyllithium; sulfuric acid; hydrogen bromide; sodium carbonate; diisopropylamine; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; water; acetic acid; toluene; xylene;
DOI:10.1002/hlca.19950780810

Reference yield:

: 60041-70-5
4-bromo-2,6-bis(bromomethyl)phenyl acetate

: 174575-30-5
(2S,5S)-5-[4-Acetoxy-5-(diethoxy-phosphorylmethyl)-4'-methyl-biphenyl-3-ylmethyl]-2-tert-butyl-3-methyl-4-oxo-imidazolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / xylene / 2 h / Heating

2: 75 percent / (i-Pr)2NH, 1.6M BuLi / tetrahydrofuran; hexane / -70 °C

3: 85 percent / 2M aq. Na₂CO₃, PPh₃, Pd(OAc)2 / ethanol; toluene / 100 °C / ultrasonic bath

With palladium diacetate; n-butyllithium; sodium carbonate; diisopropylamine; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; toluene; xylene;
DOI:10.1002/hlca.19950780810