(E)-2-(benzothiazol-2'-ylthio)-3-(4''-hydroxyphenyl)acrylonitrile

Base Information

• Chemical Name: (E)-2-(benzothiazol-2'-ylthio)-3-(4''-hydroxyphenyl)acrylonitrile
• CAS No.: 1321869-68-4
• Molecular Formula: C₁₆H₁₀N₂OS₂
• Molecular Weight: 310.4
• Mol file: 1321869-68-4.mol

Synonyms:(E)-2-(benzothiazol-2'-ylthio)-3-(4''-hydroxyphenyl)acrylonitrile

Chemical Property of (E)-2-(benzothiazol-2'-ylthio)-3-(4''-hydroxyphenyl)acrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (E)-2-(benzothiazol-2'-ylthio)-3-(4''-hydroxyphenyl)acrylonitrile

There total 2 articles about (E)-2-(benzothiazol-2'-ylthio)-3-(4''-hydroxyphenyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(1,3-benzothiazol-2-ylsulfanyl)acetonitrile (24793-01-9) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → (Z)-2-(benzothiazol-2'-ylthio)-3-(4''-hydroxyphenyl)acrylonitrile + (E)-2-(benzothiazol-2'-ylthio)-3-(4''-hydroxyphenyl)acrylonitrile (1321869-68-4)

Guidance literature:

With piperidine; In ethanol; for 4h; optical yield given as %de; stereoselective reaction; Reflux;

DOI:10.3390/molecules16076129

Reference yield:

2-Mercaptobenzothiazole (149-30-4,118090-09-8) → (Z)-2-(benzothiazol-2'-ylthio)-3-(4''-hydroxyphenyl)acrylonitrile + (E)-2-(benzothiazol-2'-ylthio)-3-(4''-hydroxyphenyl)acrylonitrile (1321869-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 2 h / Reflux

2: piperidine / ethanol / 4 h / Reflux

With piperidine; potassium carbonate; In ethanol; acetone; 2: Knoevenagel condensation;

DOI:10.3390/molecules16076129

upstream raw materials:

(1,3-benzothiazol-2-ylsulfanyl)acetonitrile

4-hydroxy-benzaldehyde

2-Mercaptobenzothiazole