2-(4-aminophenyl)-5-(4'-dimethylaminophenyl)-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-(4-aminophenyl)-5-(4'-dimethylaminophenyl)-1,3,4-oxadiazole
• CAS No.: 216483-25-9
• Molecular Formula: C₁₆H₁₆N₄O
• Molecular Weight: 280.329
• Mol file: 216483-25-9.mol

Synonyms:2-(4-aminophenyl)-5-(4'-dimethylaminophenyl)-1,3,4-oxadiazole

Chemical Property of 2-(4-aminophenyl)-5-(4'-dimethylaminophenyl)-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-aminophenyl)-5-(4'-dimethylaminophenyl)-1,3,4-oxadiazole

There total 5 articles about 2-(4-aminophenyl)-5-(4'-dimethylaminophenyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 2-(4-aminophenyl)-5-(4'-dimethylaminophenyl)-1,3,4-oxadiazole (216483-25-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride

2: hydrazine hydrate / ethanol / Reflux

3: ammonium cerium (IV) nitrate / dichloromethane / 11 h / Reflux

With hydrogenchloride; ammonium cerium (IV) nitrate; hydrazine hydrate; In ethanol; dichloromethane;

Reference yield:

N-(4-dimethylaminobenzoyl)-N'-(4-nitrobenzoyl)hydrazine → 2-(4-aminophenyl)-5-(4'-dimethylaminophenyl)-1,3,4-oxadiazole (216483-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 6 h / Reflux

2: sodium hydrogen sulfide monohydrate / ethanol / 0.5 h

With sodium hydrogen sulfide monohydrate; trichlorophosphate; In ethanol;

DOI:10.1016/j.dyepig.2017.09.010

Reference yield:

4-(dimethylamino)benzohydrazide (19353-92-5) → 2-(4-aminophenyl)-5-(4'-dimethylaminophenyl)-1,3,4-oxadiazole (216483-25-9)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 1-methyl-pyrrolidin-2-one / 7 h / 0 - 20 °C

2: trichlorophosphate / 6 h / Reflux

3: sodium hydrogen sulfide monohydrate / ethanol / 0.5 h

With pyridine; sodium hydrogen sulfide monohydrate; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; ethanol;

DOI:10.1016/j.dyepig.2017.09.010

upstream raw materials:

4-amino-benzoic acid

4-dimethylamino-benzaldehyde

4-aminobenzohydrazide

4-nitro-benzoyl chloride

Downstream raw materials:

4-(2-(4-(5-(4-(dimethylamino)phenyl)-1,3,4-oxadiazol-2-yl)phenylamino)ethoxy)-2H-chromen-2-one