[3-(4-Bromo-phenyl)-2-chloro-1-(4-nitro-phenyl)-3-oxo-propyl]-thiocarbamic acid S-methyl ester

Base Information

• Chemical Name: [3-(4-Bromo-phenyl)-2-chloro-1-(4-nitro-phenyl)-3-oxo-propyl]-thiocarbamic acid S-methyl ester
• CAS No.: 91358-52-0
• Molecular Formula: C₁₇H₁₄BrClN₂O₄S
• Molecular Weight: 457.732
• Mol file: 91358-52-0.mol

Synonyms:[3-(4-Bromo-phenyl)-2-chloro-1-(4-nitro-phenyl)-3-oxo-propyl]-thiocarbamic acid S-methyl ester

Chemical Property of [3-(4-Bromo-phenyl)-2-chloro-1-(4-nitro-phenyl)-3-oxo-propyl]-thiocarbamic acid S-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-(4-Bromo-phenyl)-2-chloro-1-(4-nitro-phenyl)-3-oxo-propyl]-thiocarbamic acid S-methyl ester

There total 2 articles about [3-(4-Bromo-phenyl)-2-chloro-1-(4-nitro-phenyl)-3-oxo-propyl]-thiocarbamic acid S-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(4-Bromo-phenyl)-[(4S,5S)-2-methylsulfanyl-4-(4-nitro-phenyl)-4,5-dihydro-oxazol-5-yl]-methanone (91358-46-2) → [3-(4-Bromo-phenyl)-2-chloro-1-(4-nitro-phenyl)-3-oxo-propyl]-thiocarbamic acid S-methyl ester (91358-52-0)

Guidance literature:

With hydrogenchloride; In dichloromethane; for 0.0833333h; Heating;

Reference yield:

trans-1-(4-bromophenyl)-2,3-epoxy-3-(4-nitrophenyl)-1-propanone (27547-06-4,32383-98-5) → [3-(4-Bromo-phenyl)-2-chloro-1-(4-nitro-phenyl)-3-oxo-propyl]-thiocarbamic acid S-methyl ester (91358-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 1) Aluminum chloride, 2) aq. KHCO₃ / CH₂Cl₂ / 20 - 25 °C

2: 97 percent / Dry hydrogen chloride / CH₂Cl₂ / 0.08 h / Heating

With hydrogenchloride; aluminium trichloride; potassium hydrogencarbonate; In dichloromethane;

upstream raw materials:

(4-Bromo-phenyl)-[(4S,5S)-2-methylsulfanyl-4-(4-nitro-phenyl)-4,5-dihydro-oxazol-5-yl]-methanone

trans-1-(4-bromophenyl)-2,3-epoxy-3-(4-nitrophenyl)-1-propanone