2,2-bis(hydroxymethyl)propyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)-phenoxy]-1-butenyl]cyclopentyl]-5-heptenoate

Base Information

Chemical Name:2,2-bis(hydroxymethyl)propyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)-phenoxy]-1-butenyl]cyclopentyl]-5-heptenoate
CAS No.:955005-75-1
Molecular Formula:C₂₈H₃₉F₃O₈
Molecular Weight:560.608
Hs Code.:

2,2-bis(hydroxymethyl)propyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)-phenoxy]-1-butenyl]cyclopentyl]-5-heptenoate

Synonyms:2,2-bis(hydroxymethyl)propyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)-phenoxy]-1-butenyl]cyclopentyl]-5-heptenoate

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Chemical Property of 2,2-bis(hydroxymethyl)propyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)-phenoxy]-1-butenyl]cyclopentyl]-5-heptenoate

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Technology Process of 2,2-bis(hydroxymethyl)propyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)-phenoxy]-1-butenyl]cyclopentyl]-5-heptenoate

There total 18 articles about 2,2-bis(hydroxymethyl)propyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)-phenoxy]-1-butenyl]cyclopentyl]-5-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-[6-[(1R,2R,3R,55)-2-[(3R)-3-(tert-butyldimethylsilyloxy)-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]-3,5-bis(triethylsilyloxy)cyclopentyl]-4-hexenyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octan

: 955005-75-1
2,2-bis(hydroxymethyl)propyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)-phenoxy]-1-butenyl]cyclopentyl]-5-heptenoate

: 2,2-bis(hydroxymethyl)propyl (5E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)-phenoxy]-1-butenyl]cyclopentyl]-5-heptenoate

Guidance literature:: 1-[6-[(1R,2R,3R,55)-2-[(3R)-3-(tert-butyldimethylsilyloxy)-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]-3,5-bis(triethylsilyloxy)cyclopentyl]-4-hexenyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octan; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 65 - 70 ℃; for 1h; Inert atmosphere;

With water; citric acid; for 0.25h; Overall yield = ~ 89 %; Overall yield = ~ 2.63 g;
DOI:10.1016/j.tet.2012.11.087

Reference yield:

: 1-[(4Z)-6-[(1R,2R,3R,5S)-2-[(3R)-3-(tert-butyldimethylsilyloxy)-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]-3,5-bis(triethylsilyloxy)cyclopentyl]-4-hexenyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octan

: 955005-75-1
2,2-bis(hydroxymethyl)propyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)-phenoxy]-1-butenyl]cyclopentyl]-5-heptenoate

Guidance literature:: 1-[(4Z)-6-[(1R,2R,3R,5S)-2-[(3R)-3-(tert-butyldimethylsilyloxy)-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]-3,5-bis(triethylsilyloxy)cyclopentyl]-4-hexenyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octan; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 60 ℃; for 2h;

With citric acid; In water; for 0.25h;