N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-1,5-dimethyl-pyrazole-3-carboxamide trifluoroacetate

Base Information

Chemical Name:N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-1,5-dimethyl-pyrazole-3-carboxamide trifluoroacetate
CAS No.:1361031-15-3
Molecular Formula:C₂HF₃O₂*C₂₃H₂₁FN₄O₄
Molecular Weight:550.466
Hs Code.:

Synonyms:N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-1,5-dimethyl-pyrazole-3-carboxamide trifluoroacetate

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Chemical Property of N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-1,5-dimethyl-pyrazole-3-carboxamide trifluoroacetate

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Technology Process of N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-1,5-dimethyl-pyrazole-3-carboxamide trifluoroacetate

There total 5 articles about N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-1,5-dimethyl-pyrazole-3-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 49783-84-8
1,5-dimethyl-1H-pyrazole-3-carbonyl chloride

: 76-05-1
trifluoroacetic acid

: 347161-74-4
4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluoroaniline

: 1361031-15-3
N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-1,5-dimethyl-pyrazole-3-carboxamide trifluoroacetate

Guidance literature:: 1,5-dimethyl-1H-pyrazole-3-carbonyl chloride; 4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluoroaniline; With pyridine; In dichloromethane; at 20 ℃;

trifluoroacetic acid; In methanol; water;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1361031-15-3
N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-1,5-dimethyl-pyrazole-3-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C / Microwave irradiation

2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / water; methanol / 48 h / 20 °C / 760.05 Torr

3: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; hydrogen; caesium carbonate; palladium 10% on activated carbon; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 13425-93-9
6,7-dimethoxyquinoline-4-ol

: 1361031-15-3
N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-1,5-dimethyl-pyrazole-3-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C / Microwave irradiation

2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / water; methanol / 48 h / 20 °C / 760.05 Torr

3: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; hydrogen; caesium carbonate; palladium 10% on activated carbon; In methanol; dichloromethane; water; N,N-dimethyl-formamide;