methyl 3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1-carboxylate

Base Information

Chemical Name:methyl 3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1-carboxylate
CAS No.:1434004-05-3
Molecular Formula:C₂₂H₂₅N₃O₃
Molecular Weight:379.459
Hs Code.:

Synonyms:methyl 3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1-carboxylate

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Chemical Property of methyl 3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1-carboxylate

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Technology Process of methyl 3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1-carboxylate

There total 3 articles about methyl 3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1434003-94-7
5-(2-azidophenyl)-3-isopropyl-2-(4-methoxybenzyl)-2,3-dihydro-1H-pyrazole-1-carboxylate

: 1434004-05-3
methyl 3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1-carboxylate

Guidance literature:: With rhodium(III) chloride hydrate; In 1,2-dimethoxyethane; at 80 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c3ob40223a

Reference yield:

: 669090-69-1
1-azido-2-ethynyl-benzene

: 1434004-05-3
methyl 3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: silver trifluoromethanesulfonate; [AuCl(IPr)] / 1,2-dichloro-ethane / 4 h / 50 °C / Inert atmosphere

2: rhodium(III) chloride hydrate / 1,2-dimethoxyethane / 4 h / 80 °C / Inert atmosphere

With rhodium(III) chloride hydrate; [AuCl(IPr)]; silver trifluoromethanesulfonate; In 1,2-dimethoxyethane; 1,2-dichloro-ethane;
DOI:10.1039/c3ob40223a

Reference yield:

: 52670-38-9
2-ethynylaniline

: 1434004-05-3
methyl 3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; sulfuric acid / water; acetonitrile; N,N-dimethyl-formamide / 0 °C

1.2: 20 °C

2.1: silver trifluoromethanesulfonate; [AuCl(IPr)] / 1,2-dichloro-ethane / 4 h / 50 °C / Inert atmosphere

3.1: rhodium(III) chloride hydrate / 1,2-dimethoxyethane / 4 h / 80 °C / Inert atmosphere

With rhodium(III) chloride hydrate; sulfuric acid; [AuCl(IPr)]; silver trifluoromethanesulfonate; sodium nitrite; In 1,2-dimethoxyethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob40223a