ethyl N-[2-{2-(benzo[d]thiazole)sulfonyl}amino-ethyl]-N-[2-[6-(benzyloxycarbonyl)amino-2-{3-(t-butoxycarbonylamino)-propyl}amino-9H-purin-9-yl]acetyl]glycinate

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Chemical Name:ethyl N-[2-{2-(benzo[d]thiazole)sulfonyl}amino-ethyl]-N-[2-[6-(benzyloxycarbonyl)amino-2-{3-(t-butoxycarbonylamino)-propyl}amino-9H-purin-9-yl]acetyl]glycinate
CAS No.:1187357-57-8
Molecular Formula:C₃₆H₄₄N₁₀O₉S₂
Molecular Weight:824.939
Hs Code.:

ethyl N-[2-{2-(benzo[d]thiazole)sulfonyl}amino-ethyl]-N-[2-[6-(benzyloxycarbonyl)amino-2-{3-(t-butoxycarbonylamino)-propyl}amino-9H-purin-9-yl]acetyl]glycinate

Synonyms:ethyl N-[2-{2-(benzo[d]thiazole)sulfonyl}amino-ethyl]-N-[2-[6-(benzyloxycarbonyl)amino-2-{3-(t-butoxycarbonylamino)-propyl}amino-9H-purin-9-yl]acetyl]glycinate

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Chemical Property of ethyl N-[2-{2-(benzo[d]thiazole)sulfonyl}amino-ethyl]-N-[2-[6-(benzyloxycarbonyl)amino-2-{3-(t-butoxycarbonylamino)-propyl}amino-9H-purin-9-yl]acetyl]glycinate

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Technology Process of ethyl N-[2-{2-(benzo[d]thiazole)sulfonyl}amino-ethyl]-N-[2-[6-(benzyloxycarbonyl)amino-2-{3-(t-butoxycarbonylamino)-propyl}amino-9H-purin-9-yl]acetyl]glycinate

There total 4 articles about ethyl N-[2-{2-(benzo[d]thiazole)sulfonyl}amino-ethyl]-N-[2-[6-(benzyloxycarbonyl)amino-2-{3-(t-butoxycarbonylamino)-propyl}amino-9H-purin-9-yl]acetyl]glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 620628-51-5
N-[2-(benzothiazole-2-sulfonylamino)ethyl]glycine ethyl ester

: 1187357-54-5
ethyl 2-[6-(benzyloxycarbonyl)amino-2-{3-(t-butoxy-carbonylamino)propyl}amino-9H-purin-9-yl]acetate

: 1187357-57-8
ethyl N-[2-{2-(benzo[d]thiazole)sulfonyl}amino-ethyl]-N-[2-[6-(benzyloxycarbonyl)amino-2-{3-(t-butoxycarbonylamino)-propyl}amino-9H-purin-9-yl]acetyl]glycinate

Guidance literature:: ethyl 2-[6-(benzyloxycarbonyl)amino-2-{3-(t-butoxy-carbonylamino)propyl}amino-9H-purin-9-yl]acetate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=3;

N-[2-(benzothiazole-2-sulfonylamino)ethyl]glycine ethyl ester; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: C₁₈H₂₉N₇O₄

: 1187357-57-8
ethyl N-[2-{2-(benzo[d]thiazole)sulfonyl}amino-ethyl]-N-[2-[6-(benzyloxycarbonyl)amino-2-{3-(t-butoxycarbonylamino)-propyl}amino-9H-purin-9-yl]acetyl]glycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sodium carbonate / methanol / 1 h / 50 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h

2.2: 2 h

3.1: N,N-dimethyl-formamide / 12 h / 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

4.2: pH 3

4.3: 20 h / 20 °C

With water; sodium hydride; sodium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1839-18-5
2-chloroadenine

: 1187357-57-8
ethyl N-[2-{2-(benzo[d]thiazole)sulfonyl}amino-ethyl]-N-[2-[6-(benzyloxycarbonyl)amino-2-{3-(t-butoxycarbonylamino)-propyl}amino-9H-purin-9-yl]acetyl]glycinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: anhydrous methoxyethanol / 24 h / Reflux

2.1: tetrahydrofuran; water / 6 h / 20 °C

3.1: water; sodium carbonate / methanol / 1 h / 50 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h

4.2: 2 h

5.1: N,N-dimethyl-formamide / 12 h / 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

6.2: pH 3

6.3: 20 h / 20 °C

With water; sodium hydride; sodium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; anhydrous methoxyethanol; water; N,N-dimethyl-formamide; mineral oil;