N-(4-hydroxy-3-methoxybenzyl)-N-(tri-(isopropyl)silyloxycarbonyl)-N-(2-(4-hydroxy-3-methoxyphenyl)ethyl)amine

Base Information

Chemical Name:N-(4-hydroxy-3-methoxybenzyl)-N-(tri-(isopropyl)silyloxycarbonyl)-N-(2-(4-hydroxy-3-methoxyphenyl)ethyl)amine
CAS No.:438036-67-0
Molecular Formula:C₂₇H₄₁NO₆Si
Molecular Weight:503.711
Hs Code.:

Synonyms:N-(4-hydroxy-3-methoxybenzyl)-N-(tri-(isopropyl)silyloxycarbonyl)-N-(2-(4-hydroxy-3-methoxyphenyl)ethyl)amine

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Chemical Property of N-(4-hydroxy-3-methoxybenzyl)-N-(tri-(isopropyl)silyloxycarbonyl)-N-(2-(4-hydroxy-3-methoxyphenyl)ethyl)amine

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Technology Process of N-(4-hydroxy-3-methoxybenzyl)-N-(tri-(isopropyl)silyloxycarbonyl)-N-(2-(4-hydroxy-3-methoxyphenyl)ethyl)amine

There total 9 articles about N-(4-hydroxy-3-methoxybenzyl)-N-(tri-(isopropyl)silyloxycarbonyl)-N-(2-(4-hydroxy-3-methoxyphenyl)ethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 438036-68-1
N-(4-benzyloxy-3-methoxybenzyl)-N-(tri-(isopropyl)silyloxycarbonyl)-N-(2-(4-benzyloxy-3-methoxyphenyl)ethyl)amine

: 438036-67-0
N-(4-hydroxy-3-methoxybenzyl)-N-(tri-(isopropyl)silyloxycarbonyl)-N-(2-(4-hydroxy-3-methoxyphenyl)ethyl)amine

Guidance literature:: With hydrogen; 10percent Pd/C; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jo020010d

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 438036-67-0
N-(4-hydroxy-3-methoxybenzyl)-N-(tri-(isopropyl)silyloxycarbonyl)-N-(2-(4-hydroxy-3-methoxyphenyl)ethyl)amine

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / NH₄OAc / acetic acid / 4 h / Heating

2: 71 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / Heating

3: 97 percent / 4 Angstroem molecular sieves / methanol / 3 h / Heating

4: 65 percent / NaBH₄ / methanol / 20 °C

5: 68 percent / Et₃N / CH₂Cl₂ / 0.58 h / -78 - 20 °C

6: 79 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; 4 A molecular sieve; ammonium acetate; hydrogen; triethylamine; 10percent Pd/C; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetic acid;
DOI:10.1021/jo020010d

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 438036-67-0
N-(4-hydroxy-3-methoxybenzyl)-N-(tri-(isopropyl)silyloxycarbonyl)-N-(2-(4-hydroxy-3-methoxyphenyl)ethyl)amine

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / K₂CO₃ / ethanol

2: 68 percent / NH₄OAc / acetic acid / 4 h / Heating

3: 71 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / Heating

4: 97 percent / 4 Angstroem molecular sieves / methanol / 3 h / Heating

5: 65 percent / NaBH₄ / methanol / 20 °C

6: 68 percent / Et₃N / CH₂Cl₂ / 0.58 h / -78 - 20 °C

7: 79 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; 4 A molecular sieve; ammonium acetate; hydrogen; potassium carbonate; triethylamine; 10percent Pd/C; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jo020010d