(R)-3-(2-Fluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester

Base Information

Chemical Name:(R)-3-(2-Fluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester
CAS No.:176435-84-0
Molecular Formula:C₂₂H₂₆FNO₄
Molecular Weight:387.451
Hs Code.:

Synonyms:(R)-3-(2-Fluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester

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Chemical Property of (R)-3-(2-Fluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester

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Technology Process of (R)-3-(2-Fluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester

There total 3 articles about (R)-3-(2-Fluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 176435-81-7
methyl 2-amino-2-methyl-3-(2-fluorophenyl)propanoate

: 182691-23-2
(S)-carbonic acid 2-methyl-1-phenylpropyl ester 4-nitrophenyl ester

: 176435-84-0
(R)-3-(2-Fluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester

: (S)-3-(2-Fluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester

Guidance literature:: In N,N-dimethyl-formamide; for 72h;
DOI:10.1021/jm950892r

Reference yield:

: 446-48-0
o-fluorobenzyl bromide

: 176435-84-0
(R)-3-(2-Fluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 4-chlorobenzaldehyde, MgSO₄, Et₃N, 2.) 1 M LHMDS, 4.) 1 M HCl

2: 26 percent / dimethylformamide / 72 h

With hydrogenchloride; 4-chlorobenzaldehyde; magnesium sulfate; triethylamine; lithium hexamethyldisilazane; In N,N-dimethyl-formamide;
DOI:10.1021/jm950892r

Reference yield:

: 34857-28-8
(S)-2-methyl-1-phenylpropan-1-ol

: 176435-84-0
(R)-3-(2-Fluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / pyridine / CH₂Cl₂ / 24 h / 0 - 20 °C

2: 26 percent / dimethylformamide / 72 h

With pyridine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950892r