(E)-7-O-benzyl-6-O-(tert-butylmethylsilyl)-2,3-dideoxy-4,5-O-isopropylidene-D-ribo-hept-2-enitol

Base Information

Chemical Name:(E)-7-O-benzyl-6-O-(tert-butylmethylsilyl)-2,3-dideoxy-4,5-O-isopropylidene-D-ribo-hept-2-enitol
CAS No.:115828-19-8
Molecular Formula:C₂₃H₃₈O₅Si
Molecular Weight:422.637
Hs Code.:

Synonyms:(E)-7-O-benzyl-6-O-(tert-butylmethylsilyl)-2,3-dideoxy-4,5-O-isopropylidene-D-ribo-hept-2-enitol

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Chemical Property of (E)-7-O-benzyl-6-O-(tert-butylmethylsilyl)-2,3-dideoxy-4,5-O-isopropylidene-D-ribo-hept-2-enitol

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Technology Process of (E)-7-O-benzyl-6-O-(tert-butylmethylsilyl)-2,3-dideoxy-4,5-O-isopropylidene-D-ribo-hept-2-enitol

There total 5 articles about (E)-7-O-benzyl-6-O-(tert-butylmethylsilyl)-2,3-dideoxy-4,5-O-isopropylidene-D-ribo-hept-2-enitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 104410-90-4
tert-butyldimethylsilyl trifluoroacetate

: 115828-18-7
ethyl(E)-7-O-benzyl-6-O-(tert-butyldimethylsilyl)-2,3-dideoxy-4,5-O-isopropylidene-D-ribo-hept-2-enoate

: 115828-19-8
(E)-7-O-benzyl-6-O-(tert-butylmethylsilyl)-2,3-dideoxy-4,5-O-isopropylidene-D-ribo-hept-2-enitol

Guidance literature:: With diisobutylaluminium hydride; In diethyl ether; at 0 ℃; for 1h;
DOI:10.1021/jo00263a017

Reference yield:

: 198969-39-0
5-O-benzyl-2,3-O-isopropylidene-D-ribofuranose

: 115828-19-8
(E)-7-O-benzyl-6-O-(tert-butylmethylsilyl)-2,3-dideoxy-4,5-O-isopropylidene-D-ribo-hept-2-enitol

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / CH₂Cl₂ / 4 h / Heating

2: 85 percent / 2,6-dimethylpyridine / CH₂Cl₂ / 0.5 h / 25 °C

3: 60 percent / ethanethiol, n-BuLi / tetrahydrofuran / 1.5 h / 25 °C

4: 89 percent / DIBAL / diethyl ether / 1 h / 0 °C

With 2,6-dimethylpyridine; n-butyllithium; diisobutylaluminium hydride; ethanethiol; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00263a017

Reference yield:

: 104410-90-4
tert-butyldimethylsilyl trifluoroacetate

: 115828-19-8
(E)-7-O-benzyl-6-O-(tert-butylmethylsilyl)-2,3-dideoxy-4,5-O-isopropylidene-D-ribo-hept-2-enitol

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 2,6-dimethylpyridine / CH₂Cl₂ / 0.5 h / 25 °C

2: 60 percent / ethanethiol, n-BuLi / tetrahydrofuran / 1.5 h / 25 °C

3: 89 percent / DIBAL / diethyl ether / 1 h / 0 °C

With 2,6-dimethylpyridine; n-butyllithium; diisobutylaluminium hydride; ethanethiol; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00263a017