1-(3-iodo-propyl)-4-(4-methoxy-phenyl)-6-trifluoromethyl-3,4-dihydro-1H-pyridin-2-one

Base Information

• Chemical Name: 1-(3-iodo-propyl)-4-(4-methoxy-phenyl)-6-trifluoromethyl-3,4-dihydro-1H-pyridin-2-one
• CAS No.: 432030-98-3
• Molecular Formula: C₁₆H₁₇F₃INO₂
• Molecular Weight: 439.216

Synonyms:1-(3-iodo-propyl)-4-(4-methoxy-phenyl)-6-trifluoromethyl-3,4-dihydro-1H-pyridin-2-one

Chemical Property of 1-(3-iodo-propyl)-4-(4-methoxy-phenyl)-6-trifluoromethyl-3,4-dihydro-1H-pyridin-2-one

Chemical Property:

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Technology Process of 1-(3-iodo-propyl)-4-(4-methoxy-phenyl)-6-trifluoromethyl-3,4-dihydro-1H-pyridin-2-one

There total 3 articles about 1-(3-iodo-propyl)-4-(4-methoxy-phenyl)-6-trifluoromethyl-3,4-dihydro-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1,3-Diiodopropane (627-31-6) + 4-(4-methoxy-phenyl)-6-trifluoromethyl-3,4-dihydro-1H-pyridin-2-one (432030-94-9) → 1-(3-iodo-propyl)-4-(4-methoxy-phenyl)-6-trifluoromethyl-3,4-dihydro-1H-pyridin-2-one (432030-98-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/ol025792b

Reference yield:

(S)-6,6,6-Trifluoro-3-(4-methoxy-phenyl)-5-oxo-hexanoic acid (432030-90-5) → 1-(3-iodo-propyl)-4-(4-methoxy-phenyl)-6-trifluoromethyl-3,4-dihydro-1H-pyridin-2-one (432030-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium carbonate / toluene / Heating

1.2: 75 percent / TsOH / toluene / Heating

2.1: 64 percent / NaH / dimethylformamide / 20 °C

With ammonium carbonate; sodium hydride; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/ol025792b

Reference yield:

2-[(S)-4,4,4-Trifluoro-3-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-1-(4-methoxy-phenyl)-butyl]-malonic acid diethyl ester → 1-(3-iodo-propyl)-4-(4-methoxy-phenyl)-6-trifluoromethyl-3,4-dihydro-1H-pyridin-2-one (432030-98-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 90 percent / H₂SO₄; HCOOH / 100 °C

2.1: ammonium carbonate / toluene / Heating

2.2: 75 percent / TsOH / toluene / Heating

3.1: 64 percent / NaH / dimethylformamide / 20 °C

With ammonium carbonate; formic acid; sulfuric acid; sodium hydride; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/ol025792b

upstream raw materials:

1,3-Diiodopropane

4-(4-methoxy-phenyl)-6-trifluoromethyl-3,4-dihydro-1H-pyridin-2-one

(S)-6,6,6-Trifluoro-3-(4-methoxy-phenyl)-5-oxo-hexanoic acid

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