4-furan-3-yl-1-(toluene-4-sulfonyl)-1H-indole-3-carbaldehyde

Base Information

• Chemical Name: 4-furan-3-yl-1-(toluene-4-sulfonyl)-1H-indole-3-carbaldehyde
• CAS No.: 916440-63-6
• Molecular Formula: C₂₀H₁₅NO₄S
• Molecular Weight: 365.409
• Mol file: 916440-63-6.mol

Synonyms:4-furan-3-yl-1-(toluene-4-sulfonyl)-1H-indole-3-carbaldehyde

Chemical Property of 4-furan-3-yl-1-(toluene-4-sulfonyl)-1H-indole-3-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-furan-3-yl-1-(toluene-4-sulfonyl)-1H-indole-3-carbaldehyde

There total 3 articles about 4-furan-3-yl-1-(toluene-4-sulfonyl)-1H-indole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-furan-3-yl-1H-indole-3-carbaldehyde (916440-59-0) + p-toluenesulfonyl chloride (98-59-9) → 4-furan-3-yl-1-(toluene-4-sulfonyl)-1H-indole-3-carbaldehyde (916440-63-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane;

DOI:10.1021/ol0620747

Reference yield:

4-bromo-1H-indole (52488-36-5) → 4-furan-3-yl-1-(toluene-4-sulfonyl)-1H-indole-3-carbaldehyde (916440-63-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / POCl₃ / 1 h / 20 °C

2: 100 percent / Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 3.5 h / Heating

3: 84 percent / DMAP; Et₃N / CH₂Cl₂

With dmap; sodium carbonate; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; 1: Vilsmeier-Hack formylation / 2: Suzuki coupling;

DOI:10.1021/ol0620747

Reference yield:

4-bromo-1H-indole-3-carbaldehyde (98600-34-1) → 4-furan-3-yl-1-(toluene-4-sulfonyl)-1H-indole-3-carbaldehyde (916440-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 3.5 h / Heating

2: 84 percent / DMAP; Et₃N / CH₂Cl₂

With dmap; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; 1: Suzuki coupling;

DOI:10.1021/ol0620747

upstream raw materials:

4-furan-3-yl-1H-indole-3-carbaldehyde

p-toluenesulfonyl chloride

4-bromo-1H-indole

4-bromo-1H-indole-3-carbaldehyde

Downstream raw materials:

1-[4-furan-3-yl-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-prop-2-en-1-ol