(S)-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone

Base Information

Chemical Name:(S)-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone
CAS No.:335160-67-3
Molecular Formula:C₂₀H₂₈N₂O₆
Molecular Weight:392.452
Hs Code.:

Synonyms:(S)-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone

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Chemical Property of (S)-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone

Chemical Property:

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Technology Process of (S)-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone

There total 6 articles about (S)-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20781-21-9
2,4-dimethoxybenzylamine hydrochloride

: 335160-67-3
(S)-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / Na(AcO)3BH; 4 Angstroem molecular sieves / 1,2-dichloro-ethane / 14 h / 20 °C

2.1: 93 percent / NaHCO₃ / ethyl acetate; H₂O / 0.33 h / 0 °C

3.1: 75 percent / Cs₂CO₃ / dimethylformamide / 2 h / 65 °C

4.1: OsO₄; NMO / 2-methyl-propan-2-ol; tetrahydrofuran; H₂O / 7 h

4.2: 96 percent / NaIO₄; NaHCO₃ / H₂O; tetrahydrofuran; 2-methyl-propan-2-ol / 1.5 h

With osmium(VIII) oxide; N-methyl-2-indolinone; 4 A molecular sieve; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; caesium carbonate; In tetrahydrofuran; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ol015504w

Reference yield:

: 95107-99-6
tert-butyl (S)-(1-oxopent-4-en-2-yl)carbamate

: 335160-67-3
(S)-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / Na(AcO)3BH; 4 Angstroem molecular sieves / 1,2-dichloro-ethane / 14 h / 20 °C

2.1: 93 percent / NaHCO₃ / ethyl acetate; H₂O / 0.33 h / 0 °C

3.1: 75 percent / Cs₂CO₃ / dimethylformamide / 2 h / 65 °C

4.1: OsO₄; NMO / 2-methyl-propan-2-ol; tetrahydrofuran; H₂O / 7 h

4.2: 96 percent / NaIO₄; NaHCO₃ / H₂O; tetrahydrofuran; 2-methyl-propan-2-ol / 1.5 h

With osmium(VIII) oxide; N-methyl-2-indolinone; 4 A molecular sieve; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; caesium carbonate; In tetrahydrofuran; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ol015504w

Reference yield:

: 90600-20-7
(2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acid

: 335160-67-3
(S)-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: 67 percent / EDC; HOBt / dimethylformamide / 24 h / 0 °C

2.1: 85 percent / LiAlH₄ / diethyl ether / 3 h / -50 - 5 °C

3.1: 90 percent / Na(AcO)3BH; 4 Angstroem molecular sieves / 1,2-dichloro-ethane / 14 h / 20 °C

4.1: 93 percent / NaHCO₃ / ethyl acetate; H₂O / 0.33 h / 0 °C

5.1: 75 percent / Cs₂CO₃ / dimethylformamide / 2 h / 65 °C

6.1: OsO₄; NMO / 2-methyl-propan-2-ol; tetrahydrofuran; H₂O / 7 h

6.2: 96 percent / NaIO₄; NaHCO₃ / H₂O; tetrahydrofuran; 2-methyl-propan-2-ol / 1.5 h

With osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; 4 A molecular sieve; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; diethyl ether; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ol015504w