(2R)-2-amino-2-<methyl>butanoic acid

Base Information

• Chemical Name: (2R)-2-amino-2-<methyl>butanoic acid
• CAS No.: 161083-40-5
• Molecular Formula: C₁₄H₂₀N₂O₄
• Molecular Weight: 280.324
• Mol file: 161083-40-5.mol

Synonyms:(2R)-2-amino-2-<methyl>butanoic acid

Chemical Property of (2R)-2-amino-2-<methyl>butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-amino-2-<methyl>butanoic acid

There total 1 articles about (2R)-2-amino-2-<methyl>butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

benzyl chloroformate (501-53-1,94274-21-2) → (2R)-2-amino-2-<methyl>butanoic acid (161083-40-5)

Guidance literature:

With phosphate buffer; In toluene; for 16h; Ambient temperature;

DOI:10.1002/hlca.19940770728

Reference yield: 73.0%

methyl chloroformate (79-22-1) + (2R)-2-amino-2-<methyl>butanoic acid (161083-40-5) → (2R)-2-<methyl>-2-butanoic acid (161083-42-7)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; for 14h; Ambient temperature;

DOI:10.1002/hlca.19940770728

Reference yield:

(2R)-2-amino-2-<methyl>butanoic acid (161083-40-5) → <(2R)-2-<methyl>-2-butanoyl>-alanine methyl ester (161083-56-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / 1 N NaOH / H₂O; dioxane / 14 h / Ambient temperature

2: diisopropylethylamine / CH₂Cl₂ / 2 h / -18 °C

3: diisopropylethylamine / CH₂Cl₂ / 1.) -18 deg C, 2 h; 2.) r.t., 12 h

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;

DOI:10.1002/hlca.19940770728

upstream raw materials:

benzyl chloroformate

Downstream raw materials:

(2R)-2-<methyl>-2-butanoic acid

<(2R)-2-<methyl>-2-butanoyl>-alanine methyl ester