(-)-(1S,2R,4S)-1-hydroxy-1-phenyl-2,5,5-trimethyl-4-<(trimethylsilyl)oxy>-3-hexanone

Base Information

Chemical Name:(-)-(1S,2R,4S)-1-hydroxy-1-phenyl-2,5,5-trimethyl-4-<(trimethylsilyl)oxy>-3-hexanone
CAS No.:133006-40-3
Molecular Formula:C₁₈H₃₀O₃Si
Molecular Weight:322.52
Hs Code.:

Synonyms:(-)-(1S,2R,4S)-1-hydroxy-1-phenyl-2,5,5-trimethyl-4-<(trimethylsilyl)oxy>-3-hexanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-(1S,2R,4S)-1-hydroxy-1-phenyl-2,5,5-trimethyl-4-<(trimethylsilyl)oxy>-3-hexanone

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Technology Process of (-)-(1S,2R,4S)-1-hydroxy-1-phenyl-2,5,5-trimethyl-4-<(trimethylsilyl)oxy>-3-hexanone

There total 36 articles about (-)-(1S,2R,4S)-1-hydroxy-1-phenyl-2,5,5-trimethyl-4-<(trimethylsilyl)oxy>-3-hexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20859-02-3
L-tert-Leucine

: 72507-44-9,72523-86-5,103957-66-0,103957-68-2,131614-05-6,131614-06-7,133006-40-3
(1R,2S,4R)-1-Hydroxy-2,5,5-trimethyl-1-phenyl-4-trimethylsilanyloxy-hexan-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / 1N H₂SO₄, NaNO₂ / H₂O / 0 - 5 °C

3: 90 percent / CH₂Cl₂ / 1 h / Ambient temperature

4: 1) 2,2,6,6-tetramethylpiperidine, ethylmagnesium bromide / 1) a) THF, 80 deg C, 24 h, b) 0 deg C, 1,5 h, 2) -78 deg C, 30 min

With 2,2,6,6-tetramethyl-piperidine; sulfuric acid; ethylmagnesium bromide; sodium nitrite; In dichloromethane; water;
DOI:10.1021/jo00007a043

Reference yield:

: 20859-02-3
L-tert-Leucine

: 72507-44-9,72523-86-5,103957-66-0,103957-68-2,131614-05-6,131614-06-7,133006-40-3
(1R,2R,4R)-1-Hydroxy-2,5,5-trimethyl-1-phenyl-4-trimethylsilanyloxy-hexan-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / 1N H₂SO₄, NaNO₂ / H₂O / 0 - 5 °C

3: 90 percent / CH₂Cl₂ / 1 h / Ambient temperature

With sulfuric acid; sodium nitrite; In dichloromethane; water;
DOI:10.1021/jo00007a043

Reference yield:

: 20859-02-3
L-tert-Leucine

: 72507-44-9,72523-86-5,103957-66-0,103957-68-2,131614-05-6,131614-06-7,133006-40-3
(1S,2S,4R)-1-Hydroxy-2,5,5-trimethyl-1-phenyl-4-trimethylsilanyloxy-hexan-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / 1N H₂SO₄, NaNO₂ / H₂O / 0 - 5 °C

3: 90 percent / CH₂Cl₂ / 1 h / Ambient temperature

With sulfuric acid; sodium nitrite; In dichloromethane; water;
DOI:10.1021/jo00007a043