12-N-(4-chlorobenzyl)sophoridine butyric acid

Base Information

• Chemical Name: 12-N-(4-chlorobenzyl)sophoridine butyric acid
• CAS No.: 1616292-49-9
• Molecular Formula: C₂₂H₃₁ClN₂O₂
• Molecular Weight: 390.953
• Mol file: 1616292-49-9.mol

Synonyms:12-N-(4-chlorobenzyl)sophoridine butyric acid

Chemical Property of 12-N-(4-chlorobenzyl)sophoridine butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 12-N-(4-chlorobenzyl)sophoridine butyric acid

There total 2 articles about 12-N-(4-chlorobenzyl)sophoridine butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sophoridine (6882-68-4) → 12-N-(4-chlorobenzyl)sophoridine butyric acid (1616292-49-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 4 h / Reflux

1.2: 2 h / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 2 h / Reflux

2.2: Reflux

3.1: hydrogenchloride; water / 3 h / Reflux

With hydrogenchloride; water; triethylamine; In water; 1,2-dichloro-ethane;

DOI:10.1016/j.ejmech.2014.04.069

Reference yield:

→ 12-N-(4-chlorobenzyl)sophoridine butyric acid (1616292-49-9)

Guidance literature:

With sodium hydroxide; for 4h; Reflux;

Reference yield: 82.0%

12-N-(4-chlorobenzyl)sophoridine butyric acid (1616292-49-9) → 12-N-4-chlorobenzylsophoridinic amide dihydrochloride

Guidance literature:

12-N-(4-chlorobenzyl)sophoridine butyric acid; With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate; In acetonitrile; at 20 ℃;

With hydrogenchloride; In diethyl ether;

DOI:10.1016/j.ejmech.2014.04.069

upstream raw materials:

sophoridine