4-Hydroxy-6-isopropyl-6-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-5,6-dihydro-pyran-2-one

Base Information

Chemical Name:4-Hydroxy-6-isopropyl-6-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-5,6-dihydro-pyran-2-one
CAS No.:261708-72-9
Molecular Formula:C₃₂H₃₂N₂O₃
Molecular Weight:492.618
Hs Code.:

Synonyms:4-Hydroxy-6-isopropyl-6-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-5,6-dihydro-pyran-2-one

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Chemical Property of 4-Hydroxy-6-isopropyl-6-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-5,6-dihydro-pyran-2-one

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Technology Process of 4-Hydroxy-6-isopropyl-6-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-5,6-dihydro-pyran-2-one

There total 7 articles about 4-Hydroxy-6-isopropyl-6-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-5,6-dihydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121077-68-7
(3-methyl-2-oxobutyl)triphenyl-arsonium bromide

: 261708-72-9
4-Hydroxy-6-isopropyl-6-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: K₂CO₃ / acetonitrile; H₂O / 18 h / 20 °C

2.1: H₂ / 5percent Pd/BaSO₄ / tetrahydrofuran / 26 h / 1654.92 Torr

3.1: 99 percent / Et₃N / dimethylformamide / 20 °C

4.1: NaH / tetrahydrofuran / 0.33 h / 0 °C

4.2: n-BuLi / tetrahydrofuran / 0.5 h / 0 °C

4.3: tetrahydrofuran / 1.5 h / 0 - 20 °C

5.1: 1 N aq. NaOH / tetrahydrofuran / 1 h

5.2: aq. HCl / pH 4.5

With sodium hydroxide; hydrogen; sodium hydride; potassium carbonate; triethylamine; 5percent Pd/BaSO₄; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0003844

Reference yield:

: 1-(1H-Imidazol-4-yl)-4-methyl-pent-1-en-3-one

: 261708-72-9
4-Hydroxy-6-isopropyl-6-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂ / 5percent Pd/BaSO₄ / tetrahydrofuran / 26 h / 1654.92 Torr

2.1: 99 percent / Et₃N / dimethylformamide / 20 °C

3.1: NaH / tetrahydrofuran / 0.33 h / 0 °C

3.2: n-BuLi / tetrahydrofuran / 0.5 h / 0 °C

3.3: tetrahydrofuran / 1.5 h / 0 - 20 °C

4.1: 1 N aq. NaOH / tetrahydrofuran / 1 h

4.2: aq. HCl / pH 4.5

With sodium hydroxide; hydrogen; sodium hydride; triethylamine; 5percent Pd/BaSO₄; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0003844

Reference yield:

: 5-hydroxy-6-methyl-3-oxo-5-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-heptanoic acid methyl ester

: 261708-72-9
4-Hydroxy-6-isopropyl-6-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-5,6-dihydro-pyran-2-one

Guidance literature:: 5-hydroxy-6-methyl-3-oxo-5-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-heptanoic acid methyl ester; With sodium hydroxide; In tetrahydrofuran; for 1h;

With hydrogenchloride; pH=4.5; Further stages.;
DOI:10.1021/jm0003844