Technology Process of diethyl 1,1-difluoro-3-hydroxy-3-phenylpropylphosphonate
There total 1 articles about diethyl 1,1-difluoro-3-hydroxy-3-phenylpropylphosphonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Diethyl difluoromethylphosphonate;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
styrene oxide;
With
titanium tetrachloride;
In
tetrahydrofuran;
at -78 ℃;
for 2h;
DOI:10.1016/j.tetlet.2008.07.146
