[5-(4-Amino-3-nitro-benzoyl)-thiophen-3-yl]-acetic acid tert-butyl ester

Base Information

Chemical Name:[5-(4-Amino-3-nitro-benzoyl)-thiophen-3-yl]-acetic acid tert-butyl ester
CAS No.:117498-85-8
Molecular Formula:C₁₇H₁₈N₂O₅S
Molecular Weight:362.406
Hs Code.:

Synonyms:[5-(4-Amino-3-nitro-benzoyl)-thiophen-3-yl]-acetic acid tert-butyl ester

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Chemical Property of [5-(4-Amino-3-nitro-benzoyl)-thiophen-3-yl]-acetic acid tert-butyl ester

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Technology Process of [5-(4-Amino-3-nitro-benzoyl)-thiophen-3-yl]-acetic acid tert-butyl ester

There total 5 articles about [5-(4-Amino-3-nitro-benzoyl)-thiophen-3-yl]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 117498-50-7
<4-(carbo-tert-butoxymethyl)-2-thienyl>(4-chloro-3-nitrophenyl)methanone

: 117498-85-8
[5-(4-Amino-3-nitro-benzoyl)-thiophen-3-yl]-acetic acid tert-butyl ester

Guidance literature:: With ammonia; In dimethyl sulfoxide; at 85 ℃; for 6h;
DOI:10.1021/jm00122a020

Reference yield:

: 117498-84-7
[5-(4-Chloro-3-nitro-benzoyl)-thiophen-3-yl]-acetyl chloride

: 117498-85-8
[5-(4-Amino-3-nitro-benzoyl)-thiophen-3-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 1 h / ice cooling

2: 60 percent / ammonia (g) / dimethylsulfoxide / 6 h / 85 °C

With ammonia; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00122a020

Reference yield:

: 117498-49-4
<4-(carboxymethyl)-2-thienyl>(4-chloro-3-nitrophenyl)methanone

: 117498-85-8
[5-(4-Amino-3-nitro-benzoyl)-thiophen-3-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / CH₂Cl₂ / 18 h

2: triethylamine / CH₂Cl₂ / 1 h / ice cooling

3: 60 percent / ammonia (g) / dimethylsulfoxide / 6 h / 85 °C

With thionyl chloride; ammonia; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00122a020