1,1-dimethylethyl (2R,5R)-5-<<4-(acetyloxy)-5-<(diethoxyphopsphoryl)methyl>(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

Base Information

• Chemical Name: 1,1-dimethylethyl (2R,5R)-5-<<4-(acetyloxy)-5-<(diethoxyphopsphoryl)methyl>(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate
• CAS No.: 174690-43-8
• Molecular Formula: C₃₃H₄₇N₂O₈P
• Molecular Weight: 630.719
• Mol file: 174690-43-8.mol

Synonyms:1,1-dimethylethyl (2R,5R)-5-<<4-(acetyloxy)-5-<(diethoxyphopsphoryl)methyl>(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

Chemical Property of 1,1-dimethylethyl (2R,5R)-5-<<4-(acetyloxy)-5-<(diethoxyphopsphoryl)methyl>(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl (2R,5R)-5-<<4-(acetyloxy)-5-<(diethoxyphopsphoryl)methyl>(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

There total 5 articles about 1,1-dimethylethyl (2R,5R)-5-<<4-(acetyloxy)-5-<(diethoxyphopsphoryl)methyl>(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

tert-butoxycarbonyl-2-(tert-butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate (119838-44-7) + diethyl <<4-(acetyloxy)-5-(bromomethyl)(1,1'-biphenyl)-3-yl>methyl>phosphonate (174575-04-3) → 1,1-dimethylethyl (2R,5R)-5-<<4-(acetyloxy)-5-<(diethoxyphopsphoryl)methyl>(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate (174690-43-8)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -70 ℃;

DOI:10.1002/hlca.19950780810

Reference yield:

4-Phenylphenol (92-69-3) → 1,1-dimethylethyl (2R,5R)-5-<<4-(acetyloxy)-5-<(diethoxyphopsphoryl)methyl>(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate (174690-43-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / KOH / H₂O / 50 °C

2: 48percent aq. HBr / acetic acid / 80 °C

3: conc. H₂SO₄ / acetic acid / 60 °C

4: 49 percent / xylene / Heating

5: 76 percent / (i-Pr)2NH, 1.6M BuLi / tetrahydrofuran; hexane / -70 °C

With potassium hydroxide; n-butyllithium; sulfuric acid; hydrogen bromide; diisopropylamine; In tetrahydrofuran; hexane; water; acetic acid; xylene;

DOI:10.1002/hlca.19950780810

Reference yield:

(4-hydroxy-[1,1′-biphenyl]-3,5-diyl)dimethanol (3173-26-0) → 1,1-dimethylethyl (2R,5R)-5-<<4-(acetyloxy)-5-<(diethoxyphopsphoryl)methyl>(1,1'-biphenyl)-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate (174690-43-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 48percent aq. HBr / acetic acid / 80 °C

2: conc. H₂SO₄ / acetic acid / 60 °C

3: 49 percent / xylene / Heating

4: 76 percent / (i-Pr)2NH, 1.6M BuLi / tetrahydrofuran; hexane / -70 °C

With n-butyllithium; sulfuric acid; hydrogen bromide; diisopropylamine; In tetrahydrofuran; hexane; acetic acid; xylene;

DOI:10.1002/hlca.19950780810

upstream raw materials:

tert-butoxycarbonyl-2-(tert-butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate

diethyl <<4-(acetyloxy)-5-(bromomethyl)(1,1'-biphenyl)-3-yl>methyl>phosphonate

4-Phenylphenol

(4-hydroxy-[1,1′-biphenyl]-3,5-diyl)dimethanol