(1s,4s)-2-{(1s)-1-[4-(allyloxy)-2,3-dimethylphenyl]ethyl}-2,5-diazabicyclo[2.2.1]heptane

Base Information

Chemical Name:(1s,4s)-2-{(1s)-1-[4-(allyloxy)-2,3-dimethylphenyl]ethyl}-2,5-diazabicyclo[2.2.1]heptane
CAS No.:873325-00-9
Molecular Formula:C₁₈H₂₆N₂O
Molecular Weight:286.417
Hs Code.:

Synonyms:(1s,4s)-2-{(1s)-1-[4-(allyloxy)-2,3-dimethylphenyl]ethyl}-2,5-diazabicyclo[2.2.1]heptane

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Chemical Property of (1s,4s)-2-{(1s)-1-[4-(allyloxy)-2,3-dimethylphenyl]ethyl}-2,5-diazabicyclo[2.2.1]heptane

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Technology Process of (1s,4s)-2-{(1s)-1-[4-(allyloxy)-2,3-dimethylphenyl]ethyl}-2,5-diazabicyclo[2.2.1]heptane

There total 5 articles about (1s,4s)-2-{(1s)-1-[4-(allyloxy)-2,3-dimethylphenyl]ethyl}-2,5-diazabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873324-99-3
tert-Butyl (1S,4S)-5-{(1S)-1-[4-(allyloxy)-2,3-dimethylphenyl]ethyl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

: 873325-00-9
(1s,4s)-2-{(1s)-1-[4-(allyloxy)-2,3-dimethylphenyl]ethyl}-2,5-diazabicyclo[2.2.1]heptane

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃; for 4h;

Reference yield:

: 2944-49-2
2,3-dimethylanisole

: 873325-00-9
(1s,4s)-2-{(1s)-1-[4-(allyloxy)-2,3-dimethylphenyl]ethyl}-2,5-diazabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 0 °C

1.2: 1 h / 0 °C

2.1: boron tribromide / dichloromethane / 20 °C

2.2: 0.5 h / 0 - 20 °C / pH 6 - 7

3.1: potassium hydroxide / acetonitrile / 0.17 h / 20 °C

3.2: 20 °C

4.1: titanium(IV) isopropylate / 3 h / 70 °C

4.2: 0.5 h / 0 °C

4.3: 0.5 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane; ethyl acetate / 4 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; potassium hydroxide; boron tribromide; aluminum (III) chloride; In 1,4-dioxane; dichloromethane; ethyl acetate; acetonitrile; 1.1: Friedel Crafts Reaction;

Reference yield:

: 873324-98-2
1-[4-(allyloxy)-2,3-dimethylphenyl]ethanone

: 873325-00-9
(1s,4s)-2-{(1s)-1-[4-(allyloxy)-2,3-dimethylphenyl]ethyl}-2,5-diazabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) isopropylate / 3 h / 70 °C

1.2: 0.5 h / 0 °C

1.3: 0.5 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; ethyl acetate / 4 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; In 1,4-dioxane; ethyl acetate;