6-(4-(6-ethoxypyridin-3-yl)phenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carbonitrile

Base Information

Chemical Name:6-(4-(6-ethoxypyridin-3-yl)phenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carbonitrile
CAS No.:1441049-39-3
Molecular Formula:C₂₇H₂₂F₃N₃O₂
Molecular Weight:477.486
Hs Code.:

Synonyms:6-(4-(6-ethoxypyridin-3-yl)phenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carbonitrile

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Chemical Property of 6-(4-(6-ethoxypyridin-3-yl)phenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carbonitrile

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Technology Process of 6-(4-(6-ethoxypyridin-3-yl)phenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carbonitrile

There total 5 articles about 6-(4-(6-ethoxypyridin-3-yl)phenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 6-(4-bromophenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carbonitrile

: 612845-44-0
2-ethoxy-5-pyridineboronic acid

: 1441049-39-3
6-(4-(6-ethoxypyridin-3-yl)phenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carbonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 22h; Inert atmosphere; Sealed tube;

Reference yield:

: 1777-53-3
1-(p-tolyl)-2-(triphenylphosphoranylidene)ethanone

: 1441049-39-3
6-(4-(6-ethoxypyridin-3-yl)phenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 150 °C / Microwave irradiation

2: ammonium hydroxide / dimethyl sulfoxide / 48 h / 20 °C / Sealed tube

3: pyridine; dmap / dichloromethane / 2.83 h / 0 - 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 22 h / 80 °C / Inert atmosphere; Sealed tube

With pyridine; dmap; ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 619-41-0
4-(bromoacetyl)toluene

: 1441049-39-3
6-(4-(6-ethoxypyridin-3-yl)phenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 2.5 h / Inert atmosphere; Reflux

1.2: 16 h / 20 °C

2.1: tetrahydrofuran / 150 °C / Microwave irradiation

3.1: ammonium hydroxide / dimethyl sulfoxide / 48 h / 20 °C / Sealed tube

4.1: pyridine; dmap / dichloromethane / 2.83 h / 0 - 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 22 h / 80 °C / Inert atmosphere; Sealed tube

With pyridine; dmap; ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;