{2-[4-(S)-(3-guanidinopropyl)-2,5-dioxo-imidazolidin-1-yl]acetyl}-Asp(O-t-Bu)-Phe-O-tBu

Base Information

Chemical Name:{2-[4-(S)-(3-guanidinopropyl)-2,5-dioxo-imidazolidin-1-yl]acetyl}-Asp(O-t-Bu)-Phe-O-tBu
CAS No.:340187-99-7
Molecular Formula:C₃₀H₄₅N₇O₈
Molecular Weight:631.729
Hs Code.:

Synonyms:{2-[4-(S)-(3-guanidinopropyl)-2,5-dioxo-imidazolidin-1-yl]acetyl}-Asp(O-t-Bu)-Phe-O-tBu

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Chemical Property of {2-[4-(S)-(3-guanidinopropyl)-2,5-dioxo-imidazolidin-1-yl]acetyl}-Asp(O-t-Bu)-Phe-O-tBu

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Technology Process of {2-[4-(S)-(3-guanidinopropyl)-2,5-dioxo-imidazolidin-1-yl]acetyl}-Asp(O-t-Bu)-Phe-O-tBu

There total 3 articles about {2-[4-(S)-(3-guanidinopropyl)-2,5-dioxo-imidazolidin-1-yl]acetyl}-Asp(O-t-Bu)-Phe-O-tBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 150376-49-1
4-(S)-(3-guanidinopropyl-2,5-dioxo-imidazolidin-1-yl)acetic acid

: 3-amino-N-(1-tert-butoxycarbonyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester; hydrochloride

: 340187-99-7
{2-[4-(S)-(3-guanidinopropyl)-2,5-dioxo-imidazolidin-1-yl]acetyl}-Asp(O-t-Bu)-Phe-O-tBu

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 22 ℃; for 16h;
DOI:10.1021/jm001068s

Reference yield:

: 22888-59-1,26340-89-6,78851-84-0,111237-99-1,18598-71-5
L-arginine methyl ester dihydrochloride

: 340187-99-7
{2-[4-(S)-(3-guanidinopropyl)-2,5-dioxo-imidazolidin-1-yl]acetyl}-Asp(O-t-Bu)-Phe-O-tBu

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethylmorpholine / dimethylformamide / 5 h / 0 - 22 °C

2: 6 N aq. HCl / 0.5 h / Heating

3: HOBt; DCC / dimethylformamide / 16 h / 0 - 22 °C

With N-ethylmorpholine;; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm001068s

Reference yield:

: 340187-94-2
(S)-(3-ethoxycarbonylmethylureido)arginine ethyl ester

: 340187-99-7
{2-[4-(S)-(3-guanidinopropyl)-2,5-dioxo-imidazolidin-1-yl]acetyl}-Asp(O-t-Bu)-Phe-O-tBu

Guidance literature:: Multi-step reaction with 2 steps

1: 6 N aq. HCl / 0.5 h / Heating

2: HOBt; DCC / dimethylformamide / 16 h / 0 - 22 °C

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm001068s