6,6-dioxo-2-phenyl-N-(4-piperidyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4-amine hydrochloride

Base Information

• Chemical Name: 6,6-dioxo-2-phenyl-N-(4-piperidyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4-amine hydrochloride
• CAS No.: 1436866-17-9
• Molecular Formula: C₁₇H₂₀N₄O₂S*ClH
• Molecular Weight: 380.898
• Mol file: 1436866-17-9.mol

Synonyms:6,6-dioxo-2-phenyl-N-(4-piperidyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4-amine hydrochloride

Chemical Property of 6,6-dioxo-2-phenyl-N-(4-piperidyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4-amine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,6-dioxo-2-phenyl-N-(4-piperidyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4-amine hydrochloride

There total 6 articles about 6,6-dioxo-2-phenyl-N-(4-piperidyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-[(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)amino]piperidine-1-carboxylate (1436866-16-8) → 6,6-dioxo-2-phenyl-N-(4-piperidyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4-amine hydrochloride (1436866-17-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2013.03.104

Reference yield:

methyl 4-oxotetrahydrothiophene-3-carboxylate (2689-68-1,99328-39-9) → 6,6-dioxo-2-phenyl-N-(4-piperidyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4-amine hydrochloride (1436866-17-9)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium methylate / methanol / 22 h / 20 - 65 °C

2: trichlorophosphate / 1 h / 90 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 96 h / 20 °C

4: N,N-dimethyl-formamide / 23 h / 70 °C

5: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; sodium methylate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.03.104

Reference yield:

ethyl 2-[4-[(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)amino]phenyl]acetate (1436866-20-4) → 6,6-dioxo-2-phenyl-N-(4-piperidyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4-amine hydrochloride (1436866-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; water / methanol; tetrahydrofuran / 1.5 h

2: N,N-dimethyl-formamide / 23 h / 70 °C

3: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; water; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.03.104

upstream raw materials:

methyl 4-oxotetrahydrothiophene-3-carboxylate

tert-butyl 4-[(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)amino]piperidine-1-carboxylate

ethyl 2-[4-[(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)amino]phenyl]acetate

2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-ol

Downstream raw materials:

2-[4-[(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)amino]-1-piperidyl]acetic acid

C₂₃H₃₀N₄O₄S