N-(2-(4-(5-(2-amino-1-phenethyl-1H-imidazol-4-yl)pentyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide hydrochloride

Base Information

• Chemical Name: N-(2-(4-(5-(2-amino-1-phenethyl-1H-imidazol-4-yl)pentyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide hydrochloride
• CAS No.: 1430883-55-8
• Molecular Formula: C₃₂H₄₃N₇O
• Molecular Weight: 541.74
• Mol file: 1430883-55-8.mol

Synonyms:N-(2-(4-(5-(2-amino-1-phenethyl-1H-imidazol-4-yl)pentyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide hydrochloride

Chemical Property of N-(2-(4-(5-(2-amino-1-phenethyl-1H-imidazol-4-yl)pentyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(4-(5-(2-amino-1-phenethyl-1H-imidazol-4-yl)pentyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide hydrochloride

There total 8 articles about N-(2-(4-(5-(2-amino-1-phenethyl-1H-imidazol-4-yl)pentyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-(4-(7-bromo-6-oxoheptyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide (1430850-15-9) + phenethylamine (64-04-0) → N-(2-(4-(5-(2-amino-1-phenethyl-1H-imidazol-4-yl)pentyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide hydrochloride (1430883-55-8)

Guidance literature:

With hydrogenchloride; CYANAMID; In ethanol; water; at 95 ℃; for 3h; pH=4.3;

DOI:10.1016/j.ejmech.2012.12.005

Reference yield:

N-(2-(4-(6-hydroxyhexyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide (1430850-09-1) → N-(2-(4-(5-(2-amino-1-phenethyl-1H-imidazol-4-yl)pentyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide hydrochloride (1430883-55-8)

Guidance literature:

Multi-step reaction with 5 steps

1: Jones reagent / acetone / 0.83 h / 0 - 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.25 h / 0 - 20 °C

3: dichloromethane; diethyl ether / 1 h / 0 °C

4: hydrogen bromide / dichloromethane; diethyl ether / 0.5 h / 0 °C

5: CYANAMID; hydrogenchloride / water; ethanol / 3 h / 95 °C / pH 4.3

With hydrogenchloride; Jones reagent; oxalyl dichloride; CYANAMID; hydrogen bromide; N,N-dimethyl-formamide; In diethyl ether; ethanol; dichloromethane; water; acetone;

DOI:10.1016/j.ejmech.2012.12.005

Reference yield:

6-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)hexanoic acid (1430850-14-8) → N-(2-(4-(5-(2-amino-1-phenethyl-1H-imidazol-4-yl)pentyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide hydrochloride (1430883-55-8)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.25 h / 0 - 20 °C

2: dichloromethane; diethyl ether / 1 h / 0 °C

3: hydrogen bromide / dichloromethane; diethyl ether / 0.5 h / 0 °C

4: CYANAMID; hydrogenchloride / water; ethanol / 3 h / 95 °C / pH 4.3

With hydrogenchloride; oxalyl dichloride; CYANAMID; hydrogen bromide; N,N-dimethyl-formamide; In diethyl ether; ethanol; dichloromethane; water;

DOI:10.1016/j.ejmech.2012.12.005

upstream raw materials:

N-(2-(4-(6-hydroxyhexyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide

6-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)hexanoic acid

N-(2-(4-(7-bromo-6-oxoheptyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-pentylbenzamide

phenethylamine

Downstream raw materials:

C₃₂H₄₃N₇O*ClH