1-{2-[5-fluoro-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylic acid

Base Information

Chemical Name:1-{2-[5-fluoro-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylic acid
CAS No.:1344995-90-9
Molecular Formula:C₂₅H₂₅F₄N₃O₄S
Molecular Weight:539.551
Hs Code.:

Synonyms:1-{2-[5-fluoro-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylic acid

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Chemical Property of 1-{2-[5-fluoro-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylic acid

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Technology Process of 1-{2-[5-fluoro-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylic acid

There total 7 articles about 1-{2-[5-fluoro-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344997-50-7
[5-fluoro-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-2-(methyloxy)phenyl]acetaldehyde

: 36476-78-5
3-azetidinecarboxylic acid

: 1344995-90-9
1-{2-[5-fluoro-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylic acid

Guidance literature:: [5-fluoro-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-2-(methyloxy)phenyl]acetaldehyde; 3-azetidinecarboxylic acid; With acetic acid; In dichloromethane; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In dichloromethane;

Reference yield:

: 67515-59-7
4-Fluoro-3-(trifluoromethyl)benzonitrile

: 1344995-90-9
1-{2-[5-fluoro-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 6.5 h / -10 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol / 8 h / 90 °C / Inert atmosphere

3.1: trichlorophosphate / 3 h / 90 °C

3.2: pH ~ 9 / Cooling with ice

4.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 1 h / 0 °C

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation; Sealed vessel; Inert atmosphere

6.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 0.17 h / 20 °C / Inert atmosphere

7.1: acetic acid / dichloromethane / 0.17 h / 20 °C

With potassium phosphate; chloro-trimethyl-silane; tert.-butylnitrite; water; sodium hydride; acetic acid; sodium iodide; sodium hydroxide; copper(ll) bromide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 5.1: Suzuki Coupling;

Reference yield:

: 213598-16-4
4-isopropoxy-3-(trifluoromethyl)benzoic acid

: 1344995-90-9
1-{2-[5-fluoro-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-2-(methyloxy)phenyl]ethyl}-3-azetidinecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 3 h / 90 °C

1.2: pH ~ 9 / Cooling with ice

2.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 1 h / 0 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation; Sealed vessel; Inert atmosphere

4.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 0.17 h / 20 °C / Inert atmosphere

5.1: acetic acid / dichloromethane / 0.17 h / 20 °C

With potassium phosphate; chloro-trimethyl-silane; tert.-butylnitrite; acetic acid; sodium iodide; copper(ll) bromide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 3.1: Suzuki Coupling;