4-[(S)-3-Morpholin-4-yl-3-oxo-2-(quinoline-8-sulfonylamino)-propyl]-thiobenzamide

Base Information

Chemical Name:4-[(S)-3-Morpholin-4-yl-3-oxo-2-(quinoline-8-sulfonylamino)-propyl]-thiobenzamide
CAS No.:104503-01-7
Molecular Formula:C₂₃H₂₄N₄O₄S₂
Molecular Weight:484.6
Hs Code.:

Synonyms:4-[(S)-3-Morpholin-4-yl-3-oxo-2-(quinoline-8-sulfonylamino)-propyl]-thiobenzamide

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Chemical Property of 4-[(S)-3-Morpholin-4-yl-3-oxo-2-(quinoline-8-sulfonylamino)-propyl]-thiobenzamide

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Technology Process of 4-[(S)-3-Morpholin-4-yl-3-oxo-2-(quinoline-8-sulfonylamino)-propyl]-thiobenzamide

There total 5 articles about 4-[(S)-3-Morpholin-4-yl-3-oxo-2-(quinoline-8-sulfonylamino)-propyl]-thiobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 104502-98-9
Quinoline-8-sulfonic acid [(S)-1-(4-cyano-benzyl)-2-morpholin-4-yl-2-oxo-ethyl]-amide

: 104503-01-7
4-[(S)-3-Morpholin-4-yl-3-oxo-2-(quinoline-8-sulfonylamino)-propyl]-thiobenzamide

Guidance literature:: With TEA; hydrogen sulfide; In pyridine;

Reference yield:

: 18704-37-5
quinoline-8-sulfonyl chloride

: 104503-01-7
4-[(S)-3-Morpholin-4-yl-3-oxo-2-(quinoline-8-sulfonylamino)-propyl]-thiobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / 1M KOH / diethyl ether / 24 h / Ambient temperature

2: 60 percent / DCC / pyridine / 1.) 2 d, 0 deg C; 2.) 2 h, room temp.

3: 99 percent / pyridine / 24 h / Ambient temperature

4: 100 percent / TEA, H₂S(gas) / pyridine

With potassium hydroxide; TEA; hydrogen sulfide; dicyclohexyl-carbodiimide; In pyridine; diethyl ether;

Reference yield:

: 104502-94-5
N_α-(8-Chinolinsulfonyl)-4-cyanphenylalanin

: 104503-01-7
4-[(S)-3-Morpholin-4-yl-3-oxo-2-(quinoline-8-sulfonylamino)-propyl]-thiobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / DCC / pyridine / 1.) 2 d, 0 deg C; 2.) 2 h, room temp.

2: 99 percent / pyridine / 24 h / Ambient temperature

3: 100 percent / TEA, H₂S(gas) / pyridine

With TEA; hydrogen sulfide; dicyclohexyl-carbodiimide; In pyridine;