1-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]ethanone

Base Information

Chemical Name:1-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]ethanone
CAS No.:885049-09-2
Molecular Formula:C₁₃H₉FN₂O₂
Molecular Weight:244.225
Hs Code.:
DSSTox Substance ID:DTXSID801207112

Synonyms:SCHEMBL2745837;MCIIATMEJRXUOB-UHFFFAOYSA-N;DTXSID801207112;1-[6-(4-fluorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]ethanone;885049-09-2;1-[6-(4-Fluorophenyl)imidazo[2,1-b]oxazol-5-yl]ethanone

Suppliers and Price of 1-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]ethanone

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:244.06480570
Heavy Atom Count:18
Complexity:331

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)C1=C(N=C2N1C=CO2)C3=CC=C(C=C3)F

Technology Process of 1-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]ethanone

There total 1 articles about 1-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 815597-09-2
6-(4-fluorophenyl)imidazo[2,1-b][1,3]oxazole

: 108-24-7
acetic anhydride

: 885049-09-2
1-[6-(4-fluorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]ethanone

Guidance literature:: With sulfuric acid; at 80 - 135 ℃; for 1.5h;

Reference yield: 100.0%

: 885049-09-2
1-[6-(4-fluorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]ethanone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 885049-10-5
3-(dimethylamino)-1-[6-(4-fluorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]prop-2-en-1-one

Guidance literature:: for 5h; Heating / reflux;

Reference yield:

: 885049-09-2
1-[6-(4-fluorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]ethanone

: N-{2-[4-({4-[6-(4-fluorophenyl)-imidazo[2,1-b][1,3]oxazol-5-yl]pyrimidin-2-yl}amino)piperidin-1-yl]-2-oxoethyl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 5 h / Heating / reflux

2: sodium ethanolate / ethanol / 15 h / Heating / reflux

3: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

4: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C

With hydrogenchloride; dmap; sodium ethanolate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;