1-(P-TOLYL)PIPERAZINE DIHYDROCHLORIDE

Base Information

• Chemical Name: 1-(P-TOLYL)PIPERAZINE DIHYDROCHLORIDE
• CAS No.: 13078-14-3
• Molecular Formula: C11H16 N2 . 2 Cl H
• Molecular Weight: 212.722
• Hs Code.: 29335995
• Mol file: 13078-14-3.mol

Synonyms:Piperazine,1-(4-methylphenyl)-, dihydrochloride (9CI); Piperazine, 1-p-tolyl-,dihydrochloride (7CI,8CI); 1-(4-Methylphenyl)piperazine dihydrochloride;1-(p-Tolyl)piperazine dihydrochloride; 4-(4-Methylphenyl)piperazinedihydrochloride

Chemical Property of 1-(P-TOLYL)PIPERAZINE DIHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.000303mmHg at 25°C
• Melting Point: 237-241 °C
• Boiling Point: 321.2°Cat760mmHg
• Flash Point: 153.8°C
• PSA: 15.27000
• Density: g/cm³
• LogP: 3.40240
• Sensitive.: Hygroscopic

Purity/Quality:

98%, ^*data from raw suppliers

1-(4-Methylphenyl)piperazineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 36/37/38-24-22
• Safety Statements: 45-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(P-TOLYL)PIPERAZINE DIHYDROCHLORIDE

There total 1 articles about 1-(P-TOLYL)PIPERAZINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + p-toluidine (106-49-0,12221-03-3) → 1-(4-methylphenyl)piperazine hydrochloride (13078-14-3,159263-04-4)

Guidance literature:

With 2-(2-methoxyethoxy)ethyl alcohol; at 150 ℃; for 12h;

DOI:10.1016/j.bmc.2016.09.005

Reference yield: 96.0%

1-(4-methylphenyl)piperazine hydrochloride (13078-14-3,159263-04-4) → (4-methylphenyl)piperazine (39593-08-3)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 0.5h; pH=11 - 12;

DOI:10.1111/cbdd.13324

Reference yield: 66.0%

5-benzhydryl-1-(3-chloropropyl)-1H-tetrazole + 1-(4-methylphenyl)piperazine hydrochloride (13078-14-3,159263-04-4) → 1-(3-(5-benzhydryl-1H-tetrazol-1-yl)propyl)-4-(4-methylphenyl)piperazine

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; at 100 ℃;

DOI:10.1016/j.bmc.2016.09.005

upstream raw materials:

bis-(2-chloroethyl)amine hydrochloride

p-toluidine

Downstream raw materials:

6-<2-<4-(4-methylphenyl)-1-piperazinyl>ethyl>-5,6,7,8-tetrahydro-1,6-naphthyridine

6-<2-<4-(4-methylphenyl)-1-piperazinyl>ethyl>-5,6,7,8-tetrahydro-1,6-naphthyridine difumarate

1-{[1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-1H-imidazol-4-yl]methyl}-4-(4-methylphenyl)piperazine

N-(4-chlorophenyl)-N-(3-(4-p-tolylpiperazin-1-yl)-propyl)-benzamide

Refernces

• 1、 Zhou, Benhua,Hong, Kwon Ho,Ji, Min,Cai, Jin. "Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands". . p. 1597 - 1609. Retrieved 2018/07/31.
• 2、 Guo, Xiaoke,Sun, Haopeng,Du, Lvpei,Huang, Lu,Xu, Jing,Zhu, Yingying,Yu, Peng,Zhang, Xiaojin,Tang, Yiqun,You, Qidong. "Discovery of aroyl piperazine derivatives as IKr & I Ks dual inhibitors for cardiac arrhythmia treatment". . p. 497 - 505. Retrieved 2014/06/23.