(2R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptanal

Base Information

Chemical Name:(2R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptanal
CAS No.:219123-86-1
Molecular Formula:C₄₃H₇₆F₂O₆Si₂
Molecular Weight:783.241
Hs Code.:

(2R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptanal

Synonyms:(2R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptanal

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Chemical Property of (2R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptanal

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Technology Process of (2R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptanal

There total 4 articles about (2R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143884-27-9
(R)-5-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-2,2-difluoro-hexanoic acid methyl ester

: 219123-86-1
(2R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptanal

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 15 min, 2.) room temp., 1.5 h

2: 1.) ZnBr₂ / 1.) CH₂Cl₂, room temp., 30 min, 2.) CH₂Cl₂, hexane, -78 deg C, 3 h

3: 81 percent / NaH / tetrahydrofuran / 2 h / 0 °C

4: 1.) trifluoroacetic anhydride, pyridine, 2.) aq. KOH / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₃CN, CH₂Cl₂, 0 deg C, 2 h

With pyridine; potassium hydroxide; n-butyllithium; sodium hydride; diisopropylamine; trifluoroacetic anhydride; zinc dibromide; In tetrahydrofuran; hexane;
DOI:10.1016/S0040-4020(98)00949-1

Reference yield:

: 197702-92-4
(2S,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-methyl-1-((S)-toluene-4-sulfinyl)-heptan-2-ol

: 219123-86-1
(2R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptanal

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / NaH / tetrahydrofuran / 2 h / 0 °C

2: 1.) trifluoroacetic anhydride, pyridine, 2.) aq. KOH / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₃CN, CH₂Cl₂, 0 deg C, 2 h

With pyridine; potassium hydroxide; sodium hydride; trifluoroacetic anhydride; In tetrahydrofuran;
DOI:10.1016/S0040-4020(98)00949-1

Reference yield:

: 197702-88-8
(R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-1-((S)-toluene-4-sulfinyl)-heptan-2-one

: 219123-86-1
(2R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptanal

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) ZnBr₂ / 1.) CH₂Cl₂, room temp., 30 min, 2.) CH₂Cl₂, hexane, -78 deg C, 3 h

2: 81 percent / NaH / tetrahydrofuran / 2 h / 0 °C

3: 1.) trifluoroacetic anhydride, pyridine, 2.) aq. KOH / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₃CN, CH₂Cl₂, 0 deg C, 2 h

With pyridine; potassium hydroxide; sodium hydride; trifluoroacetic anhydride; zinc dibromide; In tetrahydrofuran;
DOI:10.1016/S0040-4020(98)00949-1