Technology Process of dimethyl 2,7-diphenyl-9,9-dimethylfluorene-3,6-dicarboxylate
There total 4 articles about dimethyl 2,7-diphenyl-9,9-dimethylfluorene-3,6-dicarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
bromobenzene;
With
n-butyllithium;
In
tetrahydrofuran; cyclohexane;
for 0.5h;
Inert atmosphere;
With
boric acid tributyl ester;
In
tetrahydrofuran; cyclohexane;
at 20 ℃;
for 1h;
Inert atmosphere;
dimethyl 2,7-dibromo-9,9-dimethylfluorene-3,6-dicarboxylate;
Further stages;
DOI:10.1039/c2jm15868j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: 1,2-propylene cyclic carbonate; N-Bromosuccinimide / 16 h / 60 °C
3.1: potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 5 h / Reflux
4.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / Inert atmosphere
4.2: 1 h / 20 °C / Inert atmosphere
With
1,2-propylene cyclic carbonate; potassium permanganate; N-Bromosuccinimide; n-butyllithium; N-benzyl-N,N,N-triethylammonium chloride;
In
tetrahydrofuran; dichloromethane; cyclohexane;
DOI:10.1039/c2jm15868j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1,2-propylene cyclic carbonate; N-Bromosuccinimide / 16 h / 60 °C
2.1: potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 5 h / Reflux
3.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / Inert atmosphere
3.2: 1 h / 20 °C / Inert atmosphere
With
1,2-propylene cyclic carbonate; potassium permanganate; N-Bromosuccinimide; n-butyllithium; N-benzyl-N,N,N-triethylammonium chloride;
In
tetrahydrofuran; dichloromethane; cyclohexane;
DOI:10.1039/c2jm15868j
